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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA2354179 Functional Bone anabolic effect in ovariectomized F344 rat postmenopausal osteoporosis model assessed as increase in serum osteocalcin level at 10 to 30 mg/kg, po qd for 6 weeks by ELISA Rattus norvegicus 1 ALA2346568 organism-based format Scientific Literature 2. ALA2354181 Functional Bone anabolic effect in ovariectomized F344 rat postmenopausal osteoporosis model assessed as increase in areal bone mineral density of proximal tibiae at 10 to 30 mg/kg, po qd for 6 weeks by dual energy X-ray absorptiometry Rattus norvegicus 1 ALA2346568 organism-based format Scientific Literature 3. ALA2354182 Functional Bone anabolic effect in ovariectomized F344 rat postmenopausal osteoporosis model assessed as increase in areal bone mineral density of femoral diaphyses at 10 to 30 mg/kg, po qd for 6 weeks by dual energy X-ray absorptiometry Rattus norvegicus 1 ALA2346568 organism-based format Scientific Literature 4. ALA2354183 Functional Bone anabolic effect in ovariectomized F344 rat postmenopausal osteoporosis model assessed as increase in areal bone mineral density of distal femur at 10 to 30 mg/kg, po qd for 6 weeks by dual energy X-ray absorptiometry Rattus norvegicus 1 ALA2346568 organism-based format Scientific Literature 5. ALA2354186 ADME Oral bioavailability in F344 rat at 25 mg/kg Rattus norvegicus 2 ALA2346568 organism-based format Scientific Literature 6. ALA2354188 ADME AUC in F344 rat at 25 mg/kg, po Rattus norvegicus 2 ALA2346568 organism-based format Scientific Literature 7. ALA2354189 ADME AUC in F344 rat at 2 mg/kg, iv Rattus norvegicus 2 ALA2346568 organism-based format Scientific Literature 8. ALA2354190 ADME Half life in F344 rat at 25 mg/kg, po Rattus norvegicus 2 ALA2346568 organism-based format Scientific Literature 9. ALA2354191 ADME Cmax in F344 rat at 25 mg/kg, po Rattus norvegicus 2 ALA2346568 organism-based format Scientific Literature 10. ALA2354192 ADME Half life in F344 rat at 2 mg/kg, iv Rattus norvegicus 2 ALA2346568 organism-based format Scientific Literature 11. ALA2354193 ADME Volume of distribution in F344 rat at 2 mg/kg, iv Rattus norvegicus 2 ALA2346568 organism-based format Scientific Literature 12. ALA2354194 ADME Volume of distribution in F344 rat at 25 mg/kg, po Rattus norvegicus 2 ALA2346568 organism-based format Scientific Literature 13. ALA2354195 ADME Clearance in F344 rat at 2 mg/kg, iv Rattus norvegicus 2 ALA2346568 organism-based format Scientific Literature 14. ALA2354196 ADME Clearance in F344 rat at 25 mg/kg, po Rattus norvegicus 2 ALA2346568 organism-based format Scientific Literature 15. ALA2354197 ADME Metabolic stability in rat liver microsomes assessed as compound remaining after 30 mins Rattus norvegicus 5 ALA2346568 microsome format Scientific Literature 16. ALA2354199 Functional Induction of osteoblastic differentiation in mouse ST2 cells assessed as increase in alkaline phosphatase activity after 4 days by lowry method Mus musculus 24 ALA2346568 cell-based format Scientific Literature 17. ALA4388737 ADME Time dependent inhibition of CYP3A4 in human liver microsomes assessed as enzyme residual activity at 100 uM relative to control Homo sapiens 7 ALA4387729 microsome format Scientific Literature 18. ALA4388738 ADME Inhibition of CYP1A2 (unknown origin) at 10 uM relative to control Homo sapiens 7 ALA4387729 single protein format Scientific Literature 19. ALA4388743 ADME Inhibition of CYP2C9 (unknown origin) at 10 uM relative to control Homo sapiens 7 ALA4387729 single protein format Scientific Literature 20. ALA4388744 ADME Inhibition of CYP2C19 (unknown origin) at 10 uM relative to control Homo sapiens 7 ALA4387729 single protein format Scientific Literature