Displacement of [3H]Ro15-1788 from recombinant GABA-A alpha5beta2gamma2 receptor benzodiazepine binding site (unknown origin) at 10 uM after 1 hr relative to control
Displacement of [3H]Ro15-1788 from recombinant GABA-A alpha2beta2gamma2 receptor benzodiazepine binding site (unknown origin) at 10 uM after 1 hr relative to control
Anticonvulsant activity in CD1 albino mouse assessed as protection against pentylenetetrazole-induced convulsions at 10 mg/kg, po administered 30 mins prior to pentylenetetrazole challenge measured over 30 mins (Rvb = 7.1%)
Anxiolytic activity in CD1 albino mouse assessed as increase in time spent in illuminated side at 3 to 10 mg/kg, po administered 30 mins prior to testing measured for 5 mins by light-dark box test
Procognitive effect in Harlan Wistar rat assessed as decrease in exploring time of unfamiliar rat during social investigatory behaviour at 1 to 10 mg/kg, po administered 30 mins prior to testing measured for 5 mins by social learning test relative to control
Procognitive effect in Harlan Wistar rat assessed as exploring time of familiar rat during social investigatory behaviour at 3 mg/kg, po administered 30 mins prior to testing measured for 5 mins by social learning test (Rvb = 27.6 secs)
Procognitive effect in Harlan Wistar rat assessed as exploring time of familiar rat during social investigatory behaviour at 10 mg/kg, po administered 30 mins prior to testing measured for 5 mins by social learning test (Rvb = 27.6 secs)
Procognitive effect in Harlan Wistar rat assessed as exploring time of familiar rat during social investigatory behaviour at 1 mg/kg, po administered 30 mins prior to testing measured for 5 mins by social learning test (Rvb = 27.6 secs)
Antiamnesic activity in CD1 albino mouse assessed as reversal of scopolamine-induced amnesia at 1 mg/kg, po administered 30 mins prior to scopolamine challenge measured after 24 hrs by passive avoidance test
Cognitive enhancing effect in CD1 albino mouse assessed as increase in retention latency at 1 to 10 mg/kg, po administered 30 mins prior to testing measured after 24 hrs by passive avoidance test relative to control