| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2352062 | A | Oral bioavailability in rat at 5 mg/kg | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 2. | ALA2352064 | B | Selectivity ratio of IC50 for PI3Kalpha (unknown origin) to IC50 for recombinant mTOR (unknown origin) | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 3. | ALA2352065 | F | Cytotoxicity against human PC3 cells assessed as growth inhibition after 3 days by WST1 assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 4. | ALA2352066 | B | Inhibition of mTORC2 in human PC3 cells assessed as inhibition of AKTS473 phosphorylation after 1 hr by sandwich immunoassay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 5. | ALA2352067 | B | Inhibition of mTORC1 in human PC3 cells assessed as inhibition of S6 phosphorylation after 1 hr by sandwich immunoassay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 6. | ALA2352068 | B | Inhibition of PI3Kalpha (unknown origin) by mobility shift assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 7. | ALA2352069 | B | Inhibition of recombinant mTOR (unknown origin) using GST-p70S6 as substrate after 60 mins by TR-FRET analysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 8. | ALA3587517 | B | Inhibition of mTORC2 in human PC3 cells assessed as inhibition of AKT phosphorylation at S473 after 1 hr | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 9. | ALA3587519 | A | Tmax in rat at 5 mg/kg, po | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 10. | ALA3587362 | B | Inhibition of PI3K-alpha (unknown origin) by mobility shift assay | Homo sapiens | 30 | single protein format | Scientific Literature | ||
| 11. | ALA3587365 | B | Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assay | Homo sapiens | 29 | single protein format | Scientific Literature | ||
| 12. | ALA3587366 | A | Metabolic stability in rat S9 fraction assessed as compound remaining measured at 60 mins | Rattus norvegicus | 18 | assay format | Scientific Literature | ||
| 13. | ALA3587367 | A | Cmax in rat at 10 mg/kg, po | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 14. | ALA3587371 | A | Clearance in rat at 2 mg/kg, iv | Rattus norvegicus | 17 | organism-based format | Scientific Literature | ||
| 15. | ALA3587372 | B | Selectivity ratio of IC50 for PI3K-alpha (unknown origin) to IC50 for mTOR (unknown origin) | Homo sapiens | 23 | assay format | Scientific Literature | ||
| 16. | ALA5216190 | B | Inhibition of mTORC1 (unknown origin) | Homo sapiens | 29 | protein complex format | Scientific Literature | ||
| 17. | ALA5216191 | B | Inhibition of mTORC2 (unknown origin) | Homo sapiens | 19 | protein complex format | Scientific Literature | ||
| 18. | ALA5216205 | B | Inhibition of mTOR (unknown origin) | Homo sapiens | 14 | single protein format | Scientific Literature | ||
| 19. | ALA5216224 | B | Inhibition of PI3Kalpha (unknown origin) | Homo sapiens | 4 | single protein format | Scientific Literature |
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