# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2352846 | F | Antialzheimer activity in Hartley guinea pig assessed as reduction in amyloid beta (1 to 40) level in CSF at 150 mg/kg, po formulated with 0.5% HPMC/0.5% Tween 80 after 5 hrs relative to vehicle-treated control | Cavia porcellus | 1 | ALA2346596 | organism-based format | Scientific Literature | |
2. | ALA2352847 | F | Antialzheimer activity in Hartley guinea pig assessed as reduction in amyloid beta (1 to 40) level in CSF at 75 mg/kg, po formulated with 0.5% HPMC/0.5% Tween 80 after 5 hrs relative to vehicle-treated control | Cavia porcellus | 1 | ALA2346596 | organism-based format | Scientific Literature | |
3. | ALA2349934 | A | Ratio of free drug level in Hartley guinea pig brain at 75 mg/kg, po formulated with 0.5% HPMC/0.5% Tween 80 after 5 hrs to EC50 for BACE1 in HEK293 cells | 1 | ALA2346596 | organism-based format | Scientific Literature | ||
4. | ALA2350201 | A | Drug uptake in Hartley guinea pig CSF at 150 mg/kg, po formulated with 0.5% HPMC/0.5% Tween 80 after 5 hrs | Cavia porcellus | 1 | ALA2346596 | organism-based format | Scientific Literature | |
5. | ALA2350203 | A | Drug uptake in Hartley guinea pig CSF at 75 mg/kg, po formulated with 0.5% HPMC/0.5% Tween 80 after 5 hrs | Cavia porcellus | 1 | ALA2346596 | organism-based format | Scientific Literature | |
6. | ALA2350218 | A | Unbound brain-to-plasma concentration ratio in Hartley guinea pig at 75 mg/kg, po formulated with 0.5% HPMC/0.5% Tween 80 after 5 hrs | Cavia porcellus | 1 | ALA2346596 | organism-based format | Scientific Literature | |
7. | ALA2351707 | A | Free drug level in Hartley guinea pig brain at 75 mg/kg, po formulated with 0.5% HPMC/0.5% Tween 80 after 5 hrs | Cavia porcellus | 1 | ALA2346596 | organism-based format | Scientific Literature | |
8. | ALA2351983 | A | Free plasma concentration in Hartley guinea pig at 150 mg/kg, po formulated with 0.5% HPMC/0.5% Tween 80 after 5 hrs | Cavia porcellus | 1 | ALA2346596 | organism-based format | Scientific Literature | |
9. | ALA2351984 | A | Free plasma concentration in Hartley guinea pig at 75 mg/kg, po formulated with 0.5% HPMC/0.5% Tween 80 after 5 hrs | Cavia porcellus | 1 | ALA2346596 | organism-based format | Scientific Literature | |
10. | ALA2351991 | A | Clearance in human liver microsomes at 1 uM after 20 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 5 | ALA2346596 | microsome format | Scientific Literature | |
11. | ALA2351992 | A | Clearance in cynomolgus monkey liver microsomes at 1 uM after 20 mins by LC-MS/MS analysis in presence of NADPH | Macaca fascicularis | 5 | ALA2346596 | microsome format | Scientific Literature | |
12. | ALA2351993 | A | Clearance in guinea pig liver microsomes at 1 uM after 20 mins by LC-MS/MS analysis in presence of NADPH | Cavia porcellus | 5 | ALA2346596 | microsome format | Scientific Literature | |
13. | ALA2351994 | A | Clearance in rat liver microsomes at 1 uM after 20 mins by LC-MS/MS analysis in presence of NADPH | Rattus norvegicus | 5 | ALA2346596 | microsome format | Scientific Literature | |
14. | ALA2351995 | A | Fraction unbound in guinea pig brain | Cavia porcellus | 5 | ALA2346596 | tissue-based format | Scientific Literature | |
15. | ALA2351996 | A | Fraction unbound in guinea pig plasma | Cavia porcellus | 5 | ALA2346596 | cell-free format | Scientific Literature | |
16. | ALA2351997 | A | Fraction unbound in rat brain | Rattus norvegicus | 5 | ALA2346596 | tissue-based format | Scientific Literature | |
17. | ALA2351998 | A | Fraction unbound in rat plasma | Rattus norvegicus | 5 | ALA2346596 | cell-free format | Scientific Literature | |
18. | ALA2352010 | A | Clearance in mouse liver microsomes at 1 uM after 20 mins by LC-MS/MS analysis in presence of NADPH | Mus musculus | 13 | ALA2346596 | microsome format | Scientific Literature | |
19. | ALA2352013 | A | Apparent permeability from apical to basolateral side in pig LLC-PK1 cells at 1 uM after 2 hrs by LC-MS/MS analysis | Sus scrofa | 13 | ALA2346596 | cell-based format | Scientific Literature | |
20. | ALA2352014 | A | Efflux ratio of permeability from basolateral to apical over apical to basolateral side in pig LLC-PK1 cells expressing human MDR1 at 1 uM after 2 hrs by LC-MS/MS analysis | Sus scrofa | 59 | ALA2346596 | cell-based format | Scientific Literature |