Antitumor activity against ip dosed mouse EAC implanted in Swiss albino mouse assessed as inhibition of ascitic fluid administered daily for 7 days measured on 9th day relative to control
Antitumor activity against ip dosed mouse EAC implanted in Swiss albino mouse assessed as inhibition of ascitic cell administered daily for 7 days measured on 9th day relative to control
PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active
PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active
PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active
PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active
PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active
Invivo inhibition of glutamine metabolism in RHFoxn1nu mouse xenografted with human U87 cells assessed as accumulation of endogenous glutamine in tumor at 0.8 mg/kg, ip administered as single dose measured after 2 hrs by HPLC-MS analysis
Antitumor activity against human U87 cells xenografted in RHFoxn1nu mouse assessed as tumor volume at 0.8 mg/kg, ip qd for 6 days measured immediately post dose (Rvb = 409 mm3)
Antitumor activity against human U87 cells xenografted in RHFoxn1nu mouse assessed as tumor volume at 0.8 mg/kg, ip qd for 6 days measured on day 2 post dose (Rvb = 401 mm3)
Antitumor activity against human U87 cells xenografted in RHFoxn1nu mouse assessed as tumor volume at 0.8 mg/kg, ip qd for 6 days measured on day 4 post dose (Rvb = 454 mm3)
Antitumor activity against human U87 cells xenografted in RHFoxn1nu mouse assessed as tumor volume at 0.8 mg/kg, ip qd for 6 days measured on day 6 post dose (Rvb = 533 mm3)
Antitumor activity against human U87 cells xenografted in RHFoxn1nu mouse assessed as reduction in tumor volume at 0.8 mg/kg, ip qd for 6 days measured 2 to 6 days post dose