# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2379332 | Binding | Inhibition of trypsin-like activity of proteasome isolated from human Jurkat cells using Boc-LRR-AMC as substrate assessed as residual activity at 100 uM incubated for 30 mins followed by substrate addition measured for 2 hrs by fluorescence assay relative to control | Homo sapiens | 3 | ALA2375265 | cell-based format | Scientific Literature | |
2. | ALA2379333 | Binding | Inhibition of trypsin-like activity of proteasome isolated from human Jurkat cells using Boc-LRR-AMC as substrate assessed as residual activity at 50 uM incubated for 30 mins followed by substrate addition measured for 2 hrs by fluorescence assay relative to control | Homo sapiens | 3 | ALA2375265 | cell-based format | Scientific Literature | |
3. | ALA2379334 | Binding | Inhibition of trypsin-like activity of proteasome isolated from human Jurkat cells using Boc-LRR-AMC as substrate assessed as residual activity at 25 uM incubated for 30 mins followed by substrate addition measured for 2 hrs by fluorescence assay relative to control | Homo sapiens | 3 | ALA2375265 | cell-based format | Scientific Literature | |
4. | ALA2379335 | Binding | Inhibition of chymotrypsin-like activity of proteasome isolated from human Jurkat cells using Suc-LLVY-AMC as substrate assessed as residual activity at 100 uM incubated for 30 mins followed by substrate addition measured for 2 hrs by fluorescence assay relative to control | Homo sapiens | 3 | ALA2375265 | cell-based format | Scientific Literature | |
5. | ALA2379336 | Binding | Inhibition of chymotrypsin-like activity of proteasome isolated from human Jurkat cells using Suc-LLVY-AMC as substrate assessed as residual activity at 50 uM incubated for 30 mins followed by substrate addition measured for 2 hrs by fluorescence assay relative to control | Homo sapiens | 3 | ALA2375265 | cell-based format | Scientific Literature | |
6. | ALA2379507 | Binding | Inhibition of chymotrypsin-like activity of proteasome isolated from human Jurkat cells using Suc-LLVY-AMC as substrate assessed as residual activity at 25 uM incubated for 30 mins followed by substrate addition measured for 2 hrs by fluorescence assay relative to control | Homo sapiens | 3 | ALA2375265 | cell-based format | Scientific Literature | |
7. | ALA2379508 | Functional | Cell cycle arrest in human Jurkat cells assessed at 20 uM by propidium iodide staining-based FACS flow cytometric analysis | Homo sapiens | 1 | ALA2375265 | cell-based format | Scientific Literature | |
8. | ALA2379516 | Functional | Induction of apoptosis in human Jurkat cells assessed as caspase 3/7 activation at 20 uM after overnight incubation by luminescence assay | Homo sapiens | 3 | ALA2375265 | cell-based format | Scientific Literature | |
9. | ALA2379517 | ADME | Cytotoxicity against human fibroblasts assessed as growth inhibition after 48 hrs by MTT assay | Homo sapiens | 11 | ALA2375265 | cell-based format | Scientific Literature | |
10. | ALA2379553 | Functional | Cytotoxicity against human SW480 cells assessed as growth inhibition after 48 hrs by MTT assay | Homo sapiens | 11 | ALA2375265 | cell-based format | Scientific Literature | |
11. | ALA2379554 | Functional | Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by MTT assay | Homo sapiens | 11 | ALA2375265 | cell-based format | Scientific Literature | |
12. | ALA2379555 | Functional | Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay | Homo sapiens | 11 | ALA2375265 | cell-based format | Scientific Literature | |
13. | ALA2379556 | Functional | Cytotoxicity against human Jijoye cells assessed as growth inhibition after 48 hrs by MTT assay | Homo sapiens | 11 | ALA2375265 | cell-based format | Scientific Literature | |
14. | ALA2379557 | Functional | Cytotoxicity against human K562 cells assessed as growth inhibition after 48 hrs by MTT assay | Homo sapiens | 11 | ALA2375265 | cell-based format | Scientific Literature | |
15. | ALA2379558 | Functional | Cytotoxicity against human Jurkat cells assessed as growth inhibition after 48 hrs by MTT assay | Homo sapiens | 11 | ALA2375265 | cell-based format | Scientific Literature |