# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2378526 | T | Toxicity against jird infected with adult Brugia malayi assessed as behavioural change at 100 mg/kg, sc qd for 5 days measured up to 56 days | Meriones unguiculatus | 1 | organism-based format | Scientific Literature | ||
2. | ALA2378528 | F | Antifilarial activity against adult Brugia malayi infected in jirds assessed as sterile female worms recovered from host at 100 mg/kg, sc qd for 5 days measured after 56 days relative to control | Brugia malayi | 2 | organism-based format | Scientific Literature | ||
3. | ALA2378530 | F | Antifilarial activity against adult Brugia malayi infected in jirds assessed as reduction in worms recovered from host at 100 mg/kg, sc qd for 5 days measured after 56 days relative to control | Brugia malayi | 2 | organism-based format | Scientific Literature | ||
4. | ALA2378577 | F | Antifilarial activity against adult Brugia malayi infected in jirds assessed as decrease in microfilarial activity isolated from host peritoneal cavity at 100 mg/kg, sc qd for 5 days measured after 7 to 8 days | Brugia malayi | 2 | organism-based format | Scientific Literature | ||
5. | ALA2378578 | F | Ratio of diethylcarbamazine citrate IC50 to compound IC50 for microfilariae Brugia malayi | Brugia malayi | 1 | organism-based format | Scientific Literature | ||
6. | ALA2378580 | F | Ratio of diethylcarbamazine citrate LC100 to compound LC100 for female adult Brugia malayi | Brugia malayi | 2 | organism-based format | Scientific Literature | ||
7. | ALA2378581 | F | Selectivity index, ratio of CC50 for african green monkey Vero cells to IC50 for microfilariae Brugia malayi | 5 | cell-based format | Scientific Literature | |||
8. | ALA2378582 | F | Selectivity index, ratio of CC50 for african green monkey Vero cells to IC50 for female adult Brugia malayi | 3 | cell-based format | Scientific Literature | |||
9. | ALA2378583 | A | Cytotoxicity against african green monkey Vero cells | Chlorocebus sabaeus | 5 | cell-based format | Scientific Literature | ||
10. | ALA2378679 | F | Antifilarial activity against microfilariae Brugia malayi assessed as inhibition of motility after 24 hrs by microscopic analysis | Brugia malayi | 8 | organism-based format | Scientific Literature | ||
11. | ALA2378680 | F | Antifilarial activity against female adult Brugia malayi assessed as inhibition of motility after 24 hrs by microscopic analysis | Brugia malayi | 8 | organism-based format | Scientific Literature | ||
12. | ALA2378681 | F | Antifilarial activity against female adult Brugia malayi assessed as inhibition of MTT reduction at LC100 concentration after 24 hrs | Brugia malayi | 8 | organism-based format | Scientific Literature |