| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2378799 | F | Antiobesity activity in C57Bl6J mouse assessed as inhibition of corn oil-induced triacylglycerol excursion at 5 mg/kg, po administered at 30 mins post corn-oil challenge measured after 2 hrs by oral lipid tolerance test relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA2378800 | F | Antiobesity activity in C57Bl6J mouse assessed as inhibition of corn oil-induced triacylglycerol excursion at 150 mg/kg, po administered at 30 mins post corn-oil challenge measured after 2 hrs by oral lipid tolerance test relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA2378801 | A | Tmax in mouse at 100 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA2378802 | B | Inhibition of MGAT2 in mouse intestinal microsomes using 2-oleyl-sn-glycerol and [14C]-oleyl-coenzyme A as substrate after 10 to 15 mins by liquid scintillation counting analysis | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 5. | ALA2378803 | B | Inhibition of MGAT2 in human intestinal microsomes using 2-oleyl-sn-glycerol and [14C]-oleyl-coenzyme A as substrate after 10 to 15 mins by liquid scintillation counting analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 6. | ALA2378804 | B | Inhibition of human recombinant AWAT2 expressed in insect cell membrane using cetyl alcohol and [14C]oleoyl coenzyme A as substrate after 10 to 15 mins by liquid scintillation counting | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 7. | ALA2378918 | B | Inhibition of human recombinant AWAT1 expressed in insect cell membrane using palmitoleyl alcohol and [14C]stearoyl coenzyme A as substrate after 10 to 15 mins by liquid scintillation counting | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 8. | ALA2378957 | B | Inhibition of human recombinant DGAT2 using dioleoyl-sn-glycerol and [14C]oleoyl coenzyme A as substrate after 30 mins by liquid scintillation counting | Homo sapiens | 11 | single protein format | Scientific Literature | ||
| 9. | ALA2378958 | B | Inhibition of human recombinant DGAT1 expressed in Sf9 cells using dioleoyl-sn-glycerol and [14C]oleoyl coenzyme A as substrate after 30 mins by liquid scintillation counting | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 10. | ALA2378959 | A | Drug metabolism assessed as recombinant CYP3A4 (unknown origin)-mediated metabolite formation at 1 uM after 30 mins by LCMS analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 11. | ALA2378960 | A | Time dependent inhibition of CYP450 (unknown origin) | Homo sapiens | 11 | assay format | Scientific Literature | ||
| 12. | ALA2378961 | A | Inhibition of CYP450 (unknown origin) | Homo sapiens | 11 | assay format | Scientific Literature | ||
| 13. | ALA2378962 | A | Ratio of compound-glutathione adduct formation to clozapine-glutathione adduct formation in human liver microsomes at 10 umol/l after 30 mins by glutathione trapping method | Homo sapiens | 9 | microsome format | Scientific Literature | ||
| 14. | ALA2378964 | A | Apparent permeability from apical side to basolateral side of human Caco2 cells at 10 umol/l measured up to 120 mins by LCMS analysis | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 15. | ALA2378965 | P | Dissociation constant, pKa of the compound | 10 | small-molecule physicochemical format | Scientific Literature | |||
| 16. | ALA2378966 | A | Intrinsic clearance in human liver microsomes as 1 umol/l measured up to 30 mins by LC-MS analysis | Homo sapiens | 11 | microsome format | Scientific Literature | ||
| 17. | ALA2378967 | B | Inhibition of human recombinant MGAT3 expressed in insect cell membrane using 2-oleyl-sn-glycerol and [14C]-oleyl-coenzyme A as substrate after 10 to 15 mins by liquid scintillation counting analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 18. | ALA2378969 | B | Inhibition of mouse recombinant MGAT2 expressed in insect cell membrane using 2-oleoyl-sn-glycerol and oleoyl coenzyme A as substrate after 40 mins by Ellmans assay based rapidfire LCMS analysis | Mus musculus | 7 | cell-based format | Scientific Literature | ||
| 19. | ALA2378971 | B | Inhibition of human recombinant MGAT2 expressed in insect cell membrane using 2-oleoyl-sn-glycerol and oleoyl coenzyme A as substrate after 40 mins by Ellmans assay based rapidfire LCMS analysis | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 20. | ALA3135115 | A | Apparent permeability of the compound from apical to basolateral side in human Caco2 cells | Homo sapiens | 25 | cell-based format | Scientific Literature |
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