| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2383360 | A | Oral bioavailability in Sprague-Dawley rat at 1 mg/kg by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 2. | ALA2383361 | A | Cmax in Sprague-Dawley rat at 1 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 3. | ALA2383362 | A | AUC in Sprague-Dawley rat at 1 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 4. | ALA2383363 | A | Volume of distribution at steady state in Sprague-Dawley rat at 0.5 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 5. | ALA2383364 | A | Clearance in Sprague-Dawley rat at 0.5 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 6. | ALA2383365 | A | Metabolic stability in Sprague-Dawley rat hepatocytes assessed as compound remaining at 2 uM after 1 hr by LC-MS/MS analysis | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA2383371 | B | Inhibition of human PLK1 | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 8. | ALA2383375 | B | Inhibition of human FLT4 at 1 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA2383376 | B | Inhibition of human FLT3 at 1 uM relative to control | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 10. | ALA2383377 | B | Inhibition of human FGFR2 N549H mutant at 1 uM relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 11. | ALA2383378 | B | Inhibition of human AURKC at 1 uM relative to control | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 12. | ALA2383379 | B | Inhibition of human AURKB at 1 uM relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 13. | ALA2383380 | B | Inhibition of human AURKA at 1 uM relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 14. | ALA2383382 | A | Apparent permeability across MDCK cells | Canis lupus familiaris | 4 | cell-based format | Scientific Literature | ||
| 15. | ALA2383383 | P | Lipophilicity index, log K of the compound by RP-HPLC analysis | 11 | small-molecule physicochemical format | Scientific Literature | |||
| 16. | ALA2383384 | F | Antiproliferative activity against human A549 cells after 72 hrs by WST8 assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
| 17. | ALA2383385 | B | Inhibition of FLAG-tagged MPS1 phosphorylation in human RERF-LC-AI Tet-off cells after 3 hrs | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 18. | ALA2383386 | B | Selectivity ratio of IC50 for JNK1 (unknown origin) to IC50 for MPS1 (unknown origin) | Homo sapiens | 14 | assay format | Scientific Literature | ||
| 19. | ALA2383387 | B | Inhibition of JNK1 (unknown origin) using ATF2 as substrate measured after 1 hr by ELISA | Homo sapiens | 14 | single protein format | Scientific Literature | ||
| 20. | ALA2383388 | B | Inhibition of MPS1 (unknown origin) using biotin-labeled AGAGLARHTDDEMTGYVA as substrate after 90 mins by DELFIA | Homo sapiens | 16 | single protein format | Scientific Literature |
The page will load shortly, Thanks for your patience!