# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2384425 | A | Cytotoxicity against human THP1 cells assessed as cell viability measured ATP level at 10 uM after 6 hrs by celltiter-glo assay | Homo sapiens | 4 | ALA2380244 | cell-based format | Scientific Literature | |
2. | ALA2384426 | B | Agonist activity at LXRalpha in human THP1 cells assessed as effect on LPS-stimulated ABCA1 mRNA expression at 1 uM after 6 hrs by RT-qPCR analysis | Homo sapiens | 4 | ALA2380244 | cell-based format | Scientific Literature | |
3. | ALA2384427 | B | Agonist activity at REV-ERBalpha in human THP1 cells assessed as downregulation of LPS-stimulated IL-6 mRNA expression at 1 uM after 6 hrs by RT-qPCR analysis | Homo sapiens | 4 | ALA2380244 | cell-based format | Scientific Literature | |
4. | ALA2384429 | B | Agonist activity at REV-ERBalpha in human U2OS cells assessed as delay of peak of second cycle at 20 uM by luciferase reporter gene assay relative to DMSO-treated control | Homo sapiens | 18 | ALA2380244 | cell-based format | Scientific Literature | |
5. | ALA2384430 | B | Agonist activity at REV-ERBalpha in human U2OS cells assessed as suppression of BMAL1 expression at 20 uM after 40 hrs by luciferase reporter gene assay relative to DMSO-treated control | Homo sapiens | 18 | ALA2380244 | cell-based format | Scientific Literature | |
6. | ALA2384561 | B | Selectivity ratio of IC50 for LXRalpha (unknown origin) to EC50 for biotinylated REV-ERBalpha (unknown origin) | Homo sapiens | 22 | ALA2380244 | assay format | Scientific Literature | |
7. | ALA2384562 | B | Binding affinity to LXRalpha (unknown origin) by radioligand displacement assay | Homo sapiens | 25 | ALA2380244 | single protein format | Scientific Literature | |
8. | ALA2384564 | B | Agonist activity at biotinylated REV-ERBalpha (unknown origin) assessed as increase in biotinylated NCOR peptide recruitment at 10 mM after 1 hr by FRET assay relative to control | Homo sapiens | 26 | ALA2380244 | single protein format | Scientific Literature | |
9. | ALA2384565 | B | Agonist activity at biotinylated REV-ERBalpha (unknown origin) assessed as increase in biotinylated NCOR peptide recruitment after 1 hr by FRET assay | Homo sapiens | 26 | ALA2380244 | single protein format | Scientific Literature | |
10. | ALA4727677 | B | Agonist activity at Rev-Erb alpha (unknown origin) by FRET assay | Homo sapiens | 17 | ALA4725320 | single protein format | Scientific Literature |