# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2383568 | B | Inhibition of Plasmodium falciparum Enoyl-ACP reductase using Crotonoyl-CoA as substrate up to 50 uM after 20 mins by fluorescence assay | Plasmodium falciparum | 2 | ALA2380285 | assay format | Scientific Literature | |
2. | ALA2383569 | B | Inhibition of Plasmodium falciparum thioredoxin reductase using DTNB as substrate up to 50 uM after 1 hr by colorimetric assay | Plasmodium falciparum | 2 | ALA2380285 | assay format | Scientific Literature | |
3. | ALA2383570 | B | Inhibition of Saccharomyces cerevisiae DHODH expressed in Plasmodium falciparum Dd2 by [3H]-hypoxanthine incorporation assay | Saccharomyces cerevisiae | 2 | ALA2380285 | assay format | Scientific Literature | |
4. | ALA2383571 | B | Inhibition of Saccharomyces cerevisiae DHODH expressed in Plasmodium falciparum Dd2 by [3H]-hypoxanthine incorporation assay in presence of proguanil | Saccharomyces cerevisiae | 2 | ALA2380285 | assay format | Scientific Literature | |
5. | ALA2384318 | B | Inhibition of Cytochrome b-c1 complex in Plasmodium falciparum 3D7A mitochondria assessed as antimycin-sensitive decylubiquinol-cytochrome c oxidoreductase level | Plasmodium falciparum | 3 | ALA2380285 | mitochondrion format | Scientific Literature | |
6. | ALA2384319 | F | Selectivity index, ratio of CC50 for human HepG2 cells to IC50 for liver stage Plasmodium berghei | 12 | ALA2380285 | cell-based format | Scientific Literature | ||
7. | ALA2384320 | A | Cytotoxicity against human HepG2 cells after 48 hrs by Alamar Blue assay | Homo sapiens | 20 | ALA2380285 | cell-based format | Scientific Literature | |
8. | ALA2384321 | F | Inhibition of heme crystallization to hemozoin | 20 | ALA2380285 | assay format | Scientific Literature | ||
9. | ALA2384322 | B | Binding affinity to hematin (unknown origin) by UV-visible titration analysis | Not specified | 20 | ALA2380285 | assay format | Scientific Literature | |
10. | ALA2384323 | F | Ratio of primaquine IC50 to compound IC50 for liver stage Plasmodium berghei infected in human HuH7 cells | Plasmodium berghei | 2 | ALA2380285 | organism-based format | Scientific Literature | |
11. | ALA2384324 | F | Antiplasmodial activity against ring stage Plasmodium falciparum W2 infected in human RBC after 48 hrs by FACS analysis | Plasmodium falciparum | 16 | ALA2380285 | organism-based format | Scientific Literature | |
12. | ALA2384325 | F | Antiplasmodial activity against liver stage Plasmodium berghei infected in human HuH7 cells co-expressing GFP-Luccon treated for 1 hr prior to infection followed by 24 hrs after compound washout measured after 48 hrs post-infection by Alamar Blue assay | Plasmodium berghei | 20 | ALA2380285 | organism-based format | Scientific Literature |