# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2384326 | ADME | Drug level in mouse blood in mouse at 50 mg/kg measured 6 hrs postdose | Mus musculus | 1 | ALA2380263 | organism-based format | Scientific Literature | |
2. | ALA2384327 | Binding | Ratio of IWR1 EC50 to compound EC50 for tankyrase in human SW480 cells assessed as accumulation of axin2 after 24 hrs by Hoechst dye-based method | Homo sapiens | 2 | ALA2380263 | cell-based format | Scientific Literature | |
3. | ALA2384328 | ADME | Drug level in mouse blood at 50 mg/kg bid for 3 days measured 1 hr postdose | Mus musculus | 1 | ALA2380263 | organism-based format | Scientific Literature | |
4. | ALA2384329 | ADME | Drug level in mouse blood in mouse at 50 mg/kg bid for 3 days measured 6 hrs postdose | Mus musculus | 1 | ALA2380263 | organism-based format | Scientific Literature | |
5. | ALA2384331 | Functional | Unbound Cmax in po dosed CD-1 mouse to EC50 for tankyrase in human SW480 cells | 3 | ALA2380263 | organism-based format | Scientific Literature | ||
6. | ALA2384332 | Binding | Activation of rat PXR at 10 uM relative to control | Rattus norvegicus | 3 | ALA2380263 | single protein format | Scientific Literature | |
7. | ALA2384333 | ADME | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 3 | ALA2380263 | single protein format | Scientific Literature | |
8. | ALA2384334 | Binding | Inhibition of tankyrase in human SW480 cells assessed as accumulation of Axin2 after 24 hrs by Hoechst dye-based method in presence of FBA | Homo sapiens | 3 | ALA2380263 | cell-based format | Scientific Literature | |
9. | ALA2384339 | ADME | AUCt in CD-1 mouse at 30 mg/kg, po | Mus musculus | 16 | ALA2380263 | organism-based format | Scientific Literature | |
10. | ALA2384340 | ADME | Cmax in CD-1 mouse at 30 mg/kg, po | Mus musculus | 16 | ALA2380263 | organism-based format | Scientific Literature | |
11. | ALA2384341 | ADME | Plasma protein binding in mouse | Mus musculus | 8 | ALA2380263 | cell-free format | Scientific Literature | |
12. | ALA2384345 | Physicochemical | Solubility of the compound in PBS at pH 7.4 | 8 | ALA2380263 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA2384346 | Physicochemical | Solubility of the compound in 0.01N HCl | 8 | ALA2380263 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA2384347 | Physicochemical | Solubility of the compound in simulated intestinal fluid at pH 6.8 | 8 | ALA2380263 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA2384480 | ADME | Intrinsic clearance in rat liver microsomes | Rattus norvegicus | 30 | ALA2380263 | microsome format | Scientific Literature | |
16. | ALA2384481 | ADME | Intrinsic clearance in human liver microsomes | Homo sapiens | 30 | ALA2380263 | microsome format | Scientific Literature | |
17. | ALA2384482 | Binding | Inhibition of tankyrase in human SW480 cells assessed as degradation of beta catenin after 40 to 48 hrs | Homo sapiens | 31 | ALA2380263 | cell-based format | Scientific Literature | |
18. | ALA2384483 | Binding | Inhibition of tankyrase in human SW480 cells assessed as accumulation of axin2 after 24 hrs by Hoechst dye-based method | Homo sapiens | 30 | ALA2380263 | cell-based format | Scientific Literature | |
19. | ALA2384484 | Binding | Inhibition of PARP2 (unknown origin) using histone as substrate after 1 hr by luminescence assay | Homo sapiens | 5 | ALA2380263 | single protein format | Scientific Literature | |
20. | ALA2384485 | Binding | Inhibition of PARP1 (unknown origin) using histone as substrate after 1 hr by luminescence assay | Homo sapiens | 5 | ALA2380263 | single protein format | Scientific Literature |