Antileishmanial activity against amastigotes of Leishmania donovani MHOM/IN/60/Dd8 infected in golden hamster assessed as amastigote count at 50 mg/kg/day, ip administered for 5 days measured on day 7 of post last dose by Giemsa staining
Antileishmanial activity against amastigotes of Leishmania infected mouse J774A1 cells assessed as induction of nitric oxide generation after 24 hrs by ELISA (Rvb = 4.65 uM)
Antileishmanial activity against amastigotes of Leishmania infected in mouse J-774A.1 cells assessed as decrease in TNF-beta production at IC50 after 24 hrs by ELISA relative to control
Antileishmanial activity against amastigotes of Leishmania infected in mouse J-774A.1 cells assessed as decrease in IL-10 production at IC50 after 24 hrs by ELISA relative to control
Antileishmanial activity against amastigotes of Leishmania infected in mouse J-774A.1 cells assessed as increase in TNF-alpha production at IC50 after 24 hrs by ELISA relative to control
Antileishmanial activity against amastigotes of Leishmania infected in mouse J-774A.1 cells assessed as increase in IL-12 production at IC50 after 24 hrs by ELISA relative to control