# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3815700 | Binding | Inhibition of human carbonic anhydrase 1 preincubated for 6 hrs at 4 degC measured for 10 to 100 secs by stopped-flow carbon dioxide hydration assay | Homo sapiens | 6 | ALA3813660 | single protein format | Scientific Literature | |
2. | ALA3815701 | Binding | Inhibition of human carbonic anhydrase 2 preincubated for 6 hrs at 4 degC measured for 10 to 100 secs by stopped-flow carbon dioxide hydration assay | Homo sapiens | 6 | ALA3813660 | single protein format | Scientific Literature | |
3. | ALA3815702 | Binding | Inhibition of human carbonic anhydrase 9 catalytic domain preincubated for 6 hrs at 4 degC measured for 10 to 100 secs by stopped-flow carbon dioxide hydration assay | Homo sapiens | 6 | ALA3813660 | single protein format | Scientific Literature | |
4. | ALA3815703 | Binding | Inhibition of human carbonic anhydrase 12 preincubated for 6 hrs at 4 degC measured for 10 to 100 secs by stopped-flow carbon dioxide hydration assay | Homo sapiens | 6 | ALA3813660 | single protein format | Scientific Literature | |
5. | ALA3386528 | Binding | Inhibition of LDHA (unknown origin) | Homo sapiens | 8 | ALA3351282 | single protein format | Scientific Literature | |
6. | ALA2384173 | Binding | Inhibition of LDH in human HCC1954 cells assessed as lactate accumulation up to 50 uM after 6 hrs | Homo sapiens | 3 | ALA2380202 | cell-based format | Scientific Literature | |
7. | ALA2384174 | Physicochemical | Aqueous solubility of the compound in PBS buffer at pH 7.2 at 100 uM after 24 hrs | 8 | ALA2380202 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA2384175 | ADME | Clearance in human liver microsomes at 1 uM up to 60 mins | Homo sapiens | 8 | ALA2380202 | microsome format | Scientific Literature | |
9. | ALA2384178 | Binding | Inhibition of human recombinant carboxy-terminal his-tagged LDHB (1 to 333) expressed in insect cells using pyruvate as substrate after 10 mins by UV endpoint analysis | Homo sapiens | 22 | ALA2380202 | cell-based format | Scientific Literature | |
10. | ALA2384180 | Binding | Binding affinity to human recombinant carboxy-terminal avi-tagged LDHA (1 to 331) expressed in Escherichia coli by surface plasmon resonance analysis presence of NADH | Homo sapiens | 21 | ALA2380202 | assay format | Scientific Literature | |
11. | ALA2384303 | Binding | Inhibition of human recombinant carboxy-terminal his-tagged LDHA (1 to 331) expressed in Escherichia coli using pyruvate as substrate after 10 mins by UV endpoint analysis | Homo sapiens | 24 | ALA2380202 | assay format | Scientific Literature |