# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2389864 | F | Antidiabetic activity in high-fat diet fed streptozotocin-induced C57BL/6J mouse assessed as increase in insulin secretion at 30 mg/kg, po by oral glucose tolerance test | Mus musculus | 1 | ALA2384969 | organism-based format | Scientific Literature | |
2. | ALA2389865 | F | Antidiabetic activity in high-fat diet fed streptozotocin-induced C57BL/6J mouse assessed as improvement in glucose AUC at 30 mg/kg, po by oral glucose tolerance test relative to control | Mus musculus | 1 | ALA2384969 | organism-based format | Scientific Literature | |
3. | ALA2389868 | F | Potentiation of glucose-stimulated insulin secretion in human pancreatic islets at 0.01 uM to 10 uM | Homo sapiens | 1 | ALA2384969 | assay format | Scientific Literature | |
4. | ALA2389869 | F | Potentiation of glucose-stimulated insulin secretion in mouse pancreatic islets at 0.01 uM to 10 uM | Mus musculus | 1 | ALA2384969 | assay format | Scientific Literature | |
5. | ALA2389870 | B | Agonist activity at FFA1 receptor in Sprague-Dawley rat fetal intestinal cells assessed as stimulation of GIP secretion after 1 hr by ELISA relative to AM-1638 | Rattus norvegicus | 1 | ALA2384969 | assay format | Scientific Literature | |
6. | ALA2389871 | B | Agonist activity at FFA1 receptor in Sprague-Dawley rat fetal intestinal cells assessed as stimulation of GIP secretion after 1 hr by ELISA | Rattus norvegicus | 1 | ALA2384969 | assay format | Scientific Literature | |
7. | ALA2389872 | B | Agonist activity at FFA1 receptor in Sprague-Dawley rat fetal intestinal cells assessed as stimulation of GLP1 secretion after 1 hr by ELISA relative to AM-1638 | Rattus norvegicus | 1 | ALA2384969 | assay format | Scientific Literature | |
8. | ALA2389873 | B | Agonist activity at FFA1 receptor in Sprague-Dawley rat fetal intestinal cells assessed as stimulation of GLP1 secretion after 1 hr by ELISA | Rattus norvegicus | 1 | ALA2384969 | assay format | Scientific Literature | |
9. | ALA2388526 | B | Positive cooperativite binding to human FFA1 receptor expressed in CHO cell membranes assessed as enhancement of specific binding of [3H]AMG 837 by reciprocal competition assay | Homo sapiens | 2 | ALA2384969 | cell-based format | Scientific Literature | |
10. | ALA2388527 | A | Oral bioavailability in cynomolgus monkey at 2 mg/kg | Macaca fascicularis | 3 | ALA2384969 | organism-based format | Scientific Literature | |
11. | ALA2388528 | A | Oral bioavailability in Sprague-Dawley rat at 2 mg/kg | Rattus norvegicus | 3 | ALA2384969 | organism-based format | Scientific Literature | |
12. | ALA2388529 | A | Half life in cynomolgus monkey at 0.5 mg/kg, iv | Macaca fascicularis | 3 | ALA2384969 | organism-based format | Scientific Literature | |
13. | ALA2388530 | A | Half life in Sprague-Dawley rat at 0.5 mg/kg, iv | Rattus norvegicus | 3 | ALA2384969 | organism-based format | Scientific Literature | |
14. | ALA2388531 | A | Volume of distribution at steady state in cynomolgus monkey at 0.5 mg/kg, iv | Macaca fascicularis | 3 | ALA2384969 | organism-based format | Scientific Literature | |
15. | ALA2388532 | A | Volume of distribution at steady state in Sprague-Dawley rat at 0.5 mg/kg, iv | Rattus norvegicus | 3 | ALA2384969 | organism-based format | Scientific Literature | |
16. | ALA2388533 | A | Clearance in cynomolgus monkey at 0.5 mg/kg, iv | Macaca fascicularis | 3 | ALA2384969 | organism-based format | Scientific Literature | |
17. | ALA2388534 | A | Clearance in Sprague-Dawley rat at 0.5 mg/kg, iv | Rattus norvegicus | 3 | ALA2384969 | organism-based format | Scientific Literature | |
18. | ALA2388535 | B | Inhibition of rat kappa opioid receptor at 10 uM relative to control | Rattus norvegicus | 3 | ALA2384969 | single protein format | Scientific Literature | |
19. | ALA2388536 | B | Inhibition of human dopamine D1 receptor at 10 uM relative to control | Homo sapiens | 3 | ALA2384969 | single protein format | Scientific Literature | |
20. | ALA2388537 | B | Inhibition of human histamine H4 receptor at 10 uM relative to control | Homo sapiens | 3 | ALA2384969 | single protein format | Scientific Literature |