| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2389104 | F | Anxiolytic activity in ip dosed Harlan CD1 mouse assessed as inhibition of marble burying activity administered 15 to 30 mins prior to test | Mus musculus | 4 | ALA2385023 | organism-based format | Scientific Literature | |
| 2. | ALA2389105 | A | Oral bioavailability in cynomolgus monkey | Macaca fascicularis | 2 | ALA2385023 | organism-based format | Scientific Literature | |
| 3. | ALA2389106 | A | Ratio of drug level in brain to plasma in mouse at 10 mg/kg, po | Mus musculus | 2 | ALA2385023 | organism-based format | Scientific Literature | |
| 4. | ALA2389107 | A | Oral bioavailability in rat | Rattus norvegicus | 3 | ALA2385023 | organism-based format | Scientific Literature | |
| 5. | ALA2389108 | F | Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293A cells assessed as inhibition of glutamate-induced response by calcium mobilization assay | Rattus norvegicus | 4 | ALA2385023 | cell-based format | Scientific Literature | |
| 6. | ALA2389109 | A | Plasma protein binding in human | Homo sapiens | 3 | ALA2385023 | cell-free format | Scientific Literature | |
| 7. | ALA4039214 | F | Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization preincubated for 2.3 mins followed by glutamate addition measured after 1.9 mins by Fluo-4 AM dye based fluorescence assay | Rattus norvegicus | 22 | ALA4038301 | cell-based format | Scientific Literature | |
| 8. | ALA4039215 | F | Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization at 30 uM preincubated for 2.3 mins followed by glutamate addition measured after 1.9 mins by Fluo-4 AM dye based fluorescence assay relative to glutamate | Rattus norvegicus | 22 | ALA4038301 | cell-based format | Scientific Literature | |
| 9. | ALA4039216 | A | Unbound fraction in rat plasma at 5 uM after 4 hrs by equilibrium dialysis assay | Rattus norvegicus | 11 | ALA4038301 | cell-free format | Scientific Literature | |
| 10. | ALA4039217 | A | Unbound fraction in human plasma at 5 uM after 4 hrs by equilibrium dialysis assay | Homo sapiens | 11 | ALA4038301 | cell-free format | Scientific Literature | |
| 11. | ALA4039218 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 5 mins followed by NADPH addition measured after 8 mins by LC/MS/MS analysis | Homo sapiens | 13 | ALA4038301 | assay format | Scientific Literature | |
| 12. | ALA4039219 | A | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 5 mins followed by NADPH addition measured after 8 mins by LC/MS/MS analysis | Homo sapiens | 13 | ALA4038301 | assay format | Scientific Literature | |
| 13. | ALA4039220 | A | Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 5 mins followed by NADPH addition measured after 8 mins by LC/MS/MS analysis | Homo sapiens | 13 | ALA4038301 | assay format | Scientific Literature | |
| 14. | ALA4039221 | A | Inhibition of CYP1A2 in human liver microsomes using tacrine as substrate preincubated for 5 mins followed by NADPH addition measured after 8 mins by LC/MS/MS analysis | Homo sapiens | 15 | ALA4038301 | assay format | Scientific Literature | |
| 15. | ALA4039222 | A | Terminal half life in Sprague-Dawley rat at 1 mg/kg, iv up to 24 hrs post dose by LC/MS/MS analysis | Rattus norvegicus | 7 | ALA4038301 | organism-based format | Scientific Literature | |
| 16. | ALA4039223 | A | MRT in Sprague-Dawley rat at 1 mg/kg, iv up to 24 hrs post dose by LC/MS/MS analysis | Rattus norvegicus | 7 | ALA4038301 | organism-based format | Scientific Literature | |
| 17. | ALA4039224 | A | Plasma clearance in Sprague-Dawley rat at 1 mg/kg, iv up to 24 hrs post dose by LC/MS/MS Analysis | Rattus norvegicus | 8 | ALA4038301 | organism-based format | Scientific Literature | |
| 18. | ALA4039225 | A | Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv up to 24 hrs post dose by LC/MS/MS Analysis | Rattus norvegicus | 7 | ALA4038301 | organism-based format | Scientific Literature | |
| 19. | ALA4039226 | A | Fraction unbound in mouse brain at 5 uM after 6 hrs by equilibrium dialysis assay | Mus musculus | 3 | ALA4038301 | tissue-based format | Scientific Literature | |
| 20. | ALA4039227 | A | Total plasma concentration in Sprague-Dawley rat at 10 mg/kg, po after 1 hr post dose by LC/MS/MS analysis | Rattus norvegicus | 3 | ALA4038301 | organism-based format | Scientific Literature |
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