| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2390427 | A | Half life in po dosed Sprague-Dawley rat by LC/MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA2390428 | A | Oral bioavailability in Sprague-Dawley rat | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA2390429 | F | Antimalarial activity against Plasmodium falciparum VS/1 expressing DHFR quadruple mutation infected in po dosed SCID mouse assessed as reduction in parasitemia administered 3 days post infection measured on day 6 | Plasmodium falciparum | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA2390430 | F | Antiplasmodial activity against Plasmodium falciparum VS/1 expressing DHFR quadruple mutation by [3H]-hypoxanthine incorporation assay | Plasmodium falciparum | 2 | organism-based format | Scientific Literature | ||
| 5. | ALA2390431 | F | Antiplasmodial activity against wild type Plasmodium falciparum TM4 by [3H]-hypoxanthine incorporation assay | Plasmodium falciparum | 2 | organism-based format | Scientific Literature | ||
| 6. | ALA2433133 | F | Antimalarial activity against gametocytic stage of Plasmodium berghei infected in blood assessed as inhibition of ookinete formation at 10 uM after 24 hrs by Giemsa staining-based microscopic analysis relative to control | Plasmodium berghei | 10 | organism-based format | Scientific Literature | ||
| 7. | ALA2433134 | F | Antimalarial activity against mature gametocytic stage of Plasmodium falciparum assessed as inhibition of mature gamete exflagellation at 10 uM incubated for 24 hrs prior to exflagellation induction at 21 degC measured after 20 mins by microscopic analysis relative to control | Plasmodium falciparum | 18 | organism-based format | Scientific Literature | ||
| 8. | ALA2433135 | F | Antimalarial activity against sporozoite stage of Plasmodium yoelii assessed as invasion of human HepG2 cells expressing CD81 incubated for 2 hrs prior to inoculation measured after 1 hr by immunofluorescence assay in presence of penicillin/streptomycin | Plasmodium yoelii | 12 | organism-based format | Scientific Literature | ||
| 9. | ALA4181677 | B | Inhibition of Plasmodium falciparum DHFR | Plasmodium falciparum | 9 | single protein format | Scientific Literature |
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