# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2388089 | Physicochemical | Thermal stability of the compound | 2 | ALA2385035 | small-molecule physicochemical format | Scientific Literature | ||
2. | ALA2388091 | Physicochemical | Aqueous solubility of the compound | 3 | ALA2385035 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA2388092 | Functional | Antidiabetic activity in Zucker diabetic fatty rat assessed as increase in total GLP-1 level at 0.05 to 10 mg/kg, po bid for 2 weeks measured on day 14 relative to vehicle-treated control | Rattus norvegicus | 2 | ALA2385035 | organism-based format | Scientific Literature | |
4. | ALA2388093 | Functional | Antidiabetic activity in Zucker diabetic fatty rat assessed as increase in plasma insulin level at 0.05 to 10 mg/kg, po bid for 2 weeks measured on day 14 relative to vehicle-treated control | Rattus norvegicus | 2 | ALA2385035 | organism-based format | Scientific Literature | |
5. | ALA2388094 | Functional | Antidiabetic activity in Zucker diabetic fatty rat assessed as reduction in non-fasted plasma glucose level at 0.05 to 10 mg/kg, po bid for 2 weeks measured on day 14 relative to vehicle-treated control | Rattus norvegicus | 2 | ALA2385035 | organism-based format | Scientific Literature | |
6. | ALA2388095 | Functional | Antidiabetic activity in Zucker diabetic fatty rat assessed as reduction in blood HbA1c level at 0.05 to 10 mg/kg, po bid for 2 weeks measured on day 14 relative to vehicle-treated control | Rattus norvegicus | 2 | ALA2385035 | organism-based format | Scientific Literature | |
7. | ALA2388096 | Functional | Antidiabetic activity in Zucker diabetic fatty rat assessed as increase in fecal bile acid excretion at 0.05 to 10 mg/kg, po bid for 2 weeks measured for 24 hrs post last dose relative to vehicle-treated control | Rattus norvegicus | 3 | ALA2385035 | organism-based format | Scientific Literature | |
8. | ALA2388101 | Functional | In vivo inhibition of ASBT in C57BL/6J mouse assessed as increase in fecal bile acid excretion measured for 24 hrs relative to 264W94 | Mus musculus | 7 | ALA2385035 | organism-based format | Scientific Literature | |
9. | ALA2388102 | Functional | In vivo inhibition of ASBT in C57BL/6J mouse assessed as increase in fecal bile acid excretion measured for 24 hrs | Mus musculus | 7 | ALA2385035 | organism-based format | Scientific Literature | |
10. | ALA2388103 | ADME | Drug recovery in Sprague-Dawley rat feces at 10 mg/kg, po | Rattus norvegicus | 7 | ALA2385035 | organism-based format | Scientific Literature | |
11. | ALA2388851 | ADME | Half life in Sprague-Dawley rat intestine at 10 mg/kg, po | Rattus norvegicus | 6 | ALA2385035 | organism-based format | Scientific Literature | |
12. | ALA2388852 | Binding | Inhibition of rat ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysis | Rattus norvegicus | 7 | ALA2385035 | cell-based format | Scientific Literature | |
13. | ALA2388853 | Binding | Inhibition of mouse ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysis | Mus musculus | 7 | ALA2385035 | cell-based format | Scientific Literature | |
14. | ALA2388854 | ADME | Cmax in Sprague-Dawley rat portal vein blood at 10 mg/kg, po | Rattus norvegicus | 49 | ALA2385035 | organism-based format | Scientific Literature | |
15. | ALA2388855 | ADME | Cmax in Sprague-Dawley rat systemic blood at 10 mg/kg, po | Rattus norvegicus | 49 | ALA2385035 | organism-based format | Scientific Literature | |
16. | ALA2388856 | ADME | Apparent permeability in MDCK cells expressing MDR1 at 3 uM after 60 mins by LC-MS/MS analysis | Canis lupus familiaris | 49 | ALA2385035 | cell-based format | Scientific Literature | |
17. | ALA2388857 | Binding | Inhibition of human ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysis | Homo sapiens | 49 | ALA2385035 | cell-based format | Scientific Literature |