# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2388101 | Functional | In vivo inhibition of ASBT in C57BL/6J mouse assessed as increase in fecal bile acid excretion measured for 24 hrs relative to 264W94 | Mus musculus | 7 | ALA2385035 | organism-based format | Scientific Literature | |
2. | ALA2388102 | Functional | In vivo inhibition of ASBT in C57BL/6J mouse assessed as increase in fecal bile acid excretion measured for 24 hrs | Mus musculus | 7 | ALA2385035 | organism-based format | Scientific Literature | |
3. | ALA2388103 | ADME | Drug recovery in Sprague-Dawley rat feces at 10 mg/kg, po | Rattus norvegicus | 7 | ALA2385035 | organism-based format | Scientific Literature | |
4. | ALA2388851 | ADME | Half life in Sprague-Dawley rat intestine at 10 mg/kg, po | Rattus norvegicus | 6 | ALA2385035 | organism-based format | Scientific Literature | |
5. | ALA2388852 | Binding | Inhibition of rat ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysis | Rattus norvegicus | 7 | ALA2385035 | cell-based format | Scientific Literature | |
6. | ALA2388853 | Binding | Inhibition of mouse ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysis | Mus musculus | 7 | ALA2385035 | cell-based format | Scientific Literature | |
7. | ALA2388854 | ADME | Cmax in Sprague-Dawley rat portal vein blood at 10 mg/kg, po | Rattus norvegicus | 49 | ALA2385035 | organism-based format | Scientific Literature | |
8. | ALA2388855 | ADME | Cmax in Sprague-Dawley rat systemic blood at 10 mg/kg, po | Rattus norvegicus | 49 | ALA2385035 | organism-based format | Scientific Literature | |
9. | ALA2388856 | ADME | Apparent permeability in MDCK cells expressing MDR1 at 3 uM after 60 mins by LC-MS/MS analysis | Canis lupus familiaris | 49 | ALA2385035 | cell-based format | Scientific Literature | |
10. | ALA2388857 | Binding | Inhibition of human ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysis | Homo sapiens | 49 | ALA2385035 | cell-based format | Scientific Literature |