# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2390447 | F | Binding affinity to CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as dissociation half life at 10 X IC50 preincubated for 1 hr followed by 0.1 nM to 100 uM PGD2 and [35S]-GTPgammaS addition measured after 2 hrs by liquid scintillation counting analysis | Homo sapiens | 3 | ALA2384997 | cell-based format | Scientific Literature | |
2. | ALA2390449 | B | Inhibition of thromboxane A2 receptor (unknown origin) at 10 uM relative to control | Homo sapiens | 7 | ALA2384997 | single protein format | Scientific Literature | |
3. | ALA2390450 | B | Inhibition of DP1 receptor (unknown origin) at 10 uM relative to control | Homo sapiens | 7 | ALA2384997 | single protein format | Scientific Literature | |
4. | ALA2390453 | A | Oral bioavailability in rat at 10 mg/kg | Rattus norvegicus | 1 | ALA2384997 | organism-based format | Scientific Literature | |
5. | ALA2390454 | A | Volume of distribution at steady state in rat at 1 mg/kg, iv | Rattus norvegicus | 1 | ALA2384997 | organism-based format | Scientific Literature | |
6. | ALA2390455 | A | Clearance in rat at 1 mg/kg, iv | Rattus norvegicus | 1 | ALA2384997 | organism-based format | Scientific Literature | |
7. | ALA2390456 | A | Terminal half life in rat at 1 mg/kg, iv | Rattus norvegicus | 1 | ALA2384997 | organism-based format | Scientific Literature | |
8. | ALA2390607 | A | AUC ( 0 to 24 hrs) in rat at 1 mg/kg, iv | Rattus norvegicus | 1 | ALA2384997 | organism-based format | Scientific Literature | |
9. | ALA2390608 | A | Plasma protein binding in human by rapid equilibrium dialysis method | Homo sapiens | 1 | ALA2384997 | cell-free format | Scientific Literature | |
10. | ALA2390609 | A | Plasma protein binding in rat by rapid equilibrium dialysis method | Rattus norvegicus | 1 | ALA2384997 | cell-free format | Scientific Literature | |
11. | ALA2390614 | P | Lipophilicity , log D of the compound at pH 7.4 by shake-flask method | 2 | ALA2384997 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA2390616 | P | Solubility of the compound at pH 1 | 2 | ALA2384997 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA2390617 | P | Solubility of the compound at pH 7.4 | 2 | ALA2384997 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA2390618 | P | Dissociation constant, pKa of the compound by potentiometric method | 2 | ALA2384997 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA2390619 | A | Apparent permeability from apical to basolateral side in human Caco2 cells | Homo sapiens | 2 | ALA2384997 | cell-based format | Scientific Literature | |
16. | ALA2390620 | A | Apparent permeability from basolateral to apical side in human Caco2 cells | Homo sapiens | 2 | ALA2384997 | cell-based format | Scientific Literature | |
17. | ALA2390622 | B | Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins followed by PGD2 addition measured after 4 mins by side scatter analysis | Homo sapiens | 5 | ALA2384997 | single protein format | Scientific Literature | |
18. | ALA2390624 | F | Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding preincubated for 1 hr followed by 50 nM PGD2 and 0.1 nM [35S]-GTPgammaS addition measured after 2 hrs by liquid scintillation counting analysis | Homo sapiens | 34 | ALA2384997 | cell-based format | Scientific Literature | |
19. | ALA3778970 | B | Displacement of [35S]-GTPgammaS from CRTH2 receptor (unknown origin) expressed in CHOK1 cell membrane after 1 hr by liquid scintillation counter | Homo sapiens | 22 | ALA3774370 | cell-based format | Scientific Literature | |
20. | ALA3778972 | B | Antagonist activity at CRTH2 receptor (unknown origin) expressed in CHOK1 cells assessed as dissociation half life measured up to 25 hrs by GTPgammaS assay | Homo sapiens | 26 | ALA3774370 | cell-based format | Scientific Literature |