# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2393778 | B | Inhibition of NFkappaB p65 nuclear translocation in LPS-stimulated mouse RAW264.7 cells after 24 hrs by DAPI staining-based laser confocal immunofluorescent microscopic analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
2. | ALA2393780 | B | Inhibition of p38 MAPK phosphorylation in LPS-induced mouse RAW264.7 cells incubated for 2 hrs prior to LPS challenge measured after 24 hrs by Western blot analysis | Mus musculus | 2 | cell-based format | Scientific Literature | ||
3. | ALA2393781 | B | Inhibition of p38 MAPK phosphorylation in mouse RAW264.7 cells at 0.5 to 2 uM by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
4. | ALA2393783 | F | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced COX-2 expression incubated for 2 hrs prior to LPS challenge measured after 24 hrs by Western blot analysis | Mus musculus | 2 | cell-based format | Scientific Literature | ||
5. | ALA2393785 | F | Antiinflammatory activity in mouse RAW264.7 cells assessed as downregulation of LPS-induced iNOS mRNA expression incubated for 2 hrs prior to LPS challenge measured after 9 hrs by RT-PCR analysis | Mus musculus | 2 | cell-based format | Scientific Literature | ||
6. | ALA2393787 | F | Antiinflammatory activity in mouse RAW264.7 cells assessed as downregulation of LPS-induced TNFalpha expression incubated for 2 hrs prior to LPS challenge measured after 24 hrs by ELISA | Mus musculus | 2 | cell-based format | Scientific Literature | ||
7. | ALA2393788 | F | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced MMP-9 expression incubated for 2 hrs prior to LPS challenge measured after 24 hrs by gelatin zymographic analysis | Mus musculus | 2 | cell-based format | Scientific Literature | ||
8. | ALA2393791 | F | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS expression incubated for 2 hrs prior to LPS challenge measured after 24 hrs by Western blot analysis | Mus musculus | 2 | cell-based format | Scientific Literature | ||
9. | ALA2393793 | P | Induction of nitric oxide scavenging activity assessed as nitrite level at 10 uM at room temperature after 60 mins by Griess assay in presence of light and SNP | 5 | small-molecule physicochemical format | Scientific Literature | |||
10. | ALA2393794 | A | Cytotoxicity against mouse RAW264.7 cells assessed as cell viability after 24 hrs by MTS assay | Mus musculus | 8 | cell-based format | Scientific Literature | ||
11. | ALA2393795 | F | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay | Mus musculus | 8 | cell-based format | Scientific Literature | ||
12. | ALA3998952 | B | Inhibition of human liver CES1 expressed in baculovirus infected sf9 cells using o-nitrophenyl acetate as substrate monitored at 15 secs interval for 5 mins | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
13. | ALA3998953 | B | Inhibition of human intestinal CES2 expressed in baculovirus infected sf9 cells using o-nitrophenyl acetate as substrate monitored at 15 secs interval for 5 mins | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
14. | ALA3998954 | B | Inhibition of human liver CES1 expressed in baculovirus infected sf9 cells at 10 uM using o-nitrophenyl acetate as substrate monitored at 15 secs interval for 5 mins relative to control | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
15. | ALA3998955 | B | Inhibition of human intestinal CES2 expressed in baculovirus infected sf9 cells at 10 uM using o-nitrophenyl acetate as substrate monitored at 15 secs interval for 5 mins relative to control | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
16. | ALA3998957 | B | Inhibition of human AChE at 10 uM using acetylthiocholine as substrate by spectrophotometric method relative to control | Homo sapiens | 22 | single protein format | Scientific Literature | ||
17. | ALA3998958 | B | Selectivity ratio of Ki for human intestinal CES2 to Ki for human liver CES1 | Homo sapiens | 9 | assay format | Scientific Literature | ||
18. | ALA3998959 | B | Inhibition of human liver CES1 expressed in U373MG cells assessed as oseltamivir carboxylate formation at 5 uM using oseltamivir as substrate preincubated for 30 mins followed by compound washout and subsequent compound/substrate addition measured after 30 mins by UPLC-MS method relative to control | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
19. | ALA3998960 | B | Inhibition of human intestinal CES2 expressed in U373MG cells assessed as 7-ethyl-10-hydroxycamptothecin formation at 5 uM using irinotecan as substrate preincubated for 1 hr followed by substrate addition measured after 5 mins by HPLC method relative to control | Homo sapiens | 13 | cell-based format | Scientific Literature |