# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2396026 | A | P-glycoprotein (unknown origin)-mediated permeability assessed as efflux ratio from basolateral to apical side to apical to basolateral side at 24 hrs | Not specified | 4 | assay format | Scientific Literature | ||
2. | ALA2396027 | F | Antihypertensive activity in spontaneously hypertensive rat model assessed as reduction in heart rate at 10 mg/kg for 7 days | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
3. | ALA2396028 | F | Antihypertensive activity in telemeterized wild type mouse assessed as reduction in systolic BP at 30 mg/kg/day for 11 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
4. | ALA2396029 | A | P-glycoprotein (unknown origin)-mediated permeability assessed as efflux ratio from basolateral to apical side to apical to basolateral side at 4 hrs | Not specified | 4 | assay format | Scientific Literature | ||
5. | ALA2396030 | A | Ratio of drug level in brain to plasma of spontaneously hypertensive rat at 10 mg/kg | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
6. | ALA2396031 | F | Antihypertensive activity in telemeterized 11beta-HSD1 KO mouse assessed as reduction in systolic BP at 30 mg/kg/day for 11 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
7. | ALA2396032 | A | Drug level in spontaneously hypertensive rat CSF at 10 mg/kg measured after 24 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
8. | ALA2396033 | A | Total drug level in spontaneously hypertensive rat brain at 10 mg/kg measured after 24 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
9. | ALA2396034 | A | Free drug level in spontaneously hypertensive rat brain at 10 mg/kg measured after 24 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
10. | ALA2396035 | A | Drug level in spontaneously hypertensive rat CSF at 10 mg/kg measured after 4 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
11. | ALA2396036 | A | Free plasma concentration in spontaneously hypertensive rat at 10 mg/kg measured after 24 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
12. | ALA2396037 | A | Total drug level in spontaneously hypertensive rat brain at 10 mg/kg measured after 4 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
13. | ALA2396038 | A | Free drug level in spontaneously hypertensive rat brain at 10 mg/kg measured after 4 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
14. | ALA2396039 | A | Free plasma concentration in spontaneously hypertensive rat at 10 mg/kg measured after 4 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
15. | ALA2396040 | A | Plasma concentration in spontaneously hypertensive rat model at 10 mg/kg measured after 24 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
16. | ALA2396041 | A | Plasma concentration in spontaneously hypertensive rat model at 10 mg/kg measured after 4 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
17. | ALA2396175 | F | Antihypertensive activity in spontaneously hypertensive rat model assessed as reduction in diastolic BP at 10 mg/kg for 7 days | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
18. | ALA2396176 | F | Antihypertensive activity in spontaneously hypertensive rat model assessed as reduction in systolic BP at 10 mg/kg for 7 days | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
19. | ALA2396178 | B | Inhibition of rat 11beta-HSD1 | Rattus norvegicus | 4 | single protein format | Scientific Literature | ||
20. | ALA2396179 | B | Inhibition of human microsomal 11beta-HSD2 assessed as inhibition of conversion of radiolabeled cortisone to radiolabeled cortisol by cell-based assay | Homo sapiens | 4 | cell-based format | Scientific Literature |