| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2400636 | F | Inhibition of DNP-HSA-induced anaphylaxis in C57BL/6 mouse assessed as change in body temperature at 20 uM, ip treated prior to DNP-HSA-challenge measured every 5 mins for 1 hr | Mus musculus | 1 | ALA2396532 | organism-based format | Scientific Literature | |
| 2. | ALA2400637 | F | Effect on anti-DNP-IgE-induced degranulation in PEP-deficient C57BL/6 mouse BMMC assessed as hexosaminidase release at 5 to 20 uM after 1 hr by spectrophotometric analysis | Mus musculus | 1 | ALA2396532 | assay format | Scientific Literature | |
| 3. | ALA2400638 | B | Inhibition of PEP in C57BL/6 mouse BMMC assessed as reduction in anti-DNP-IgE-induced degranulation by measuring beta-hexosaminidase release at 5 to 20 uM after 1 hr by spectrophotometric analysis | Mus musculus | 1 | ALA2396532 | single protein format | Scientific Literature | |
| 4. | ALA2400639 | B | Inhibition of PEP in mouse CD4 and CD8 double positive thymocytes assessed as increase in Nur77 expression at 15 uM after 3.5 hrs by GFP-based FACS analysis | Mus musculus | 1 | ALA2396532 | assay format | Scientific Literature | |
| 5. | ALA2400640 | B | Inhibition of PEP in mouse CD4 and CD8 double positive thymocytes assessed as increase in CD69 expression at 15 uM after 3.5 hrs by FACS analysis | Mus musculus | 1 | ALA2396532 | assay format | Scientific Literature | |
| 6. | ALA2400641 | B | Inhibition of LYP in human Jurkat T cells expressing SV-40 large T antigen assessed as increase in CD69 expression at 15 uM after 4.5 hrs by FITC staining-based FACS analysis | Homo sapiens | 1 | ALA2396532 | cell-based format | Scientific Literature | |
| 7. | ALA2400642 | B | Inhibition of LYP in human Jurkat T cells expressing SV-40 large T antigen assessed as increase in C305-stimulated ZAP-70 phosphorylation at Tyr319 at 15 uM preincubated for 30 mins prior to C305-treatment by FACS analysis | Homo sapiens | 1 | ALA2396532 | cell-based format | Scientific Literature | |
| 8. | ALA2400643 | B | Inhibition of LYP in human Jurkat T cells expressing SV-40 large T antigen assessed as increase in ZAP-70 phosphorylation at Tyr319 at 15 uM after 30 mins by FACS analysis | Homo sapiens | 1 | ALA2396532 | cell-based format | Scientific Literature | |
| 9. | ALA2400644 | B | Competitive inhibition of N-terminal 6xHis-tagged LYP catalytic domain (1 to 303) (unknown origin) expressed in Escherichia coli BL21(DE3) using pNPP as substrate by Dixon plot analysis | Homo sapiens | 2 | ALA2396532 | assay format | Scientific Literature | |
| 10. | ALA2400645 | B | Reversible inhibition of N-terminal 6xHis-tagged LYP catalytic domain (1 to 303) (unknown origin) expressed in Escherichia coli BL21(DE3) using pNPP as substrate preincubated with enzyme for 30 mins prior to substrate addition by spectrophotometric analysis | Homo sapiens | 1 | ALA2396532 | assay format | Scientific Literature | |
| 11. | ALA2400646 | B | Reversible inhibition of N-terminal 6xHis-tagged LYP catalytic domain (1 to 303) (unknown origin) expressed in Escherichia coli BL21(DE3) using pNPP as substrate preincubated with substrate followed by enzyme addition by spectrophotometric analysis | Homo sapiens | 1 | ALA2396532 | assay format | Scientific Literature | |
| 12. | ALA2400647 | B | Selectivity ratio of IC50 for LMWPTP (unknown origin) to IC50 for N-terminal 6xHis-tagged LYP catalytic domain (1 to 303) (unknown origin) | Homo sapiens | 1 | ALA2396532 | assay format | Scientific Literature | |
| 13. | ALA2400648 | B | Selectivity ratio of IC50 for MKP3 (unknown origin) to IC50 for N-terminal 6xHis-tagged LYP catalytic domain (1 to 303) (unknown origin) | Homo sapiens | 1 | ALA2396532 | assay format | Scientific Literature | |
| 14. | ALA2401010 | B | Selectivity ratio of IC50 for CDC14 (unknown origin) to IC50 for N-terminal 6xHis-tagged LYP catalytic domain (1 to 303) (unknown origin) | Homo sapiens | 1 | ALA2396532 | assay format | Scientific Literature | |
| 15. | ALA2401011 | B | Selectivity ratio of IC50 for VHZ (unknown origin) to IC50 for N-terminal 6xHis-tagged LYP catalytic domain (1 to 303) (unknown origin) | Homo sapiens | 1 | ALA2396532 | assay format | Scientific Literature | |
| 16. | ALA2401012 | B | Selectivity ratio of IC50 for VHX (unknown origin) to IC50 for N-terminal 6xHis-tagged LYP catalytic domain (1 to 303) (unknown origin) | Homo sapiens | 1 | ALA2396532 | assay format | Scientific Literature | |
| 17. | ALA2401013 | B | Selectivity ratio of IC50 for VHR (unknown origin) to IC50 for N-terminal 6xHis-tagged LYP catalytic domain (1 to 303) (unknown origin) | Homo sapiens | 1 | ALA2396532 | assay format | Scientific Literature | |
| 18. | ALA2401014 | B | Selectivity ratio of IC50 for laforin (unknown origin) to IC50 for N-terminal 6xHis-tagged LYP catalytic domain (1 to 303) (unknown origin) | Homo sapiens | 1 | ALA2396532 | assay format | Scientific Literature | |
| 19. | ALA2401015 | B | Selectivity ratio of IC50 for PTPmu (unknown origin) to IC50 for N-terminal 6xHis-tagged LYP catalytic domain (1 to 303) (unknown origin) | Homo sapiens | 1 | ALA2396532 | assay format | Scientific Literature | |
| 20. | ALA2401016 | B | Selectivity ratio of IC50 for PTPsigma (unknown origin) to IC50 for N-terminal 6xHis-tagged LYP catalytic domain (1 to 303) (unknown origin) | Homo sapiens | 1 | ALA2396532 | assay format | Scientific Literature |
The page will load shortly, Thanks for your patience!