# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2400873 | B | Inhibition of HDAC8 in C57BL/6 mouse embryonic fibroblasts assessed as induction of histone H3 hyperacetylation in promoter region of Lhx1 at 100 nM after 24 hrs by ChIP analysis | Mus musculus | 2 | ALA2396564 | single protein format | Scientific Literature | |
2. | ALA2400874 | B | Inhibition of HDAC8 in C57BL/6 mouse embryonic fibroblasts assessed as induction of histone H3 hyperacetylation in promoter region of Otx2 at 100 nM after 24 hrs by ChIP analysis | Mus musculus | 2 | ALA2396564 | single protein format | Scientific Literature | |
3. | ALA2400877 | B | Inhibition of HDAC8 in C57BL/6 mouse embryonic fibroblasts assessed as upregulation of Lhx1 expression at 100 nM after 24 hrs by qPCR analysis relative to control | Mus musculus | 2 | ALA2396564 | assay format | Scientific Literature | |
4. | ALA2400878 | B | Inhibition of HDAC8 in C57BL/6 mouse embryonic fibroblasts assessed as upregulation of Otx2 expression at 100 nM after 24 hrs by qPCR analysis relative to control | Mus musculus | 2 | ALA2396564 | assay format | Scientific Literature | |
5. | ALA2400879 | B | Inhibition of HDAC8 in C57BL/6 mouse embryonic fibroblasts assessed as induction of histone H3 hyperacetylation in promoter region of Rex1 at 100 nM after 24 hrs by ChIP analysis | Mus musculus | 2 | ALA2396564 | single protein format | Scientific Literature | |
6. | ALA2400880 | B | Inhibition of HDAC8 in C57BL/6 mouse embryonic fibroblasts assessed as induction of histone H3 hyperacetylation in promoter region of Cdh1 at 100 nM after 24 hrs by ChIP analysis | Mus musculus | 2 | ALA2396564 | single protein format | Scientific Literature | |
7. | ALA2400881 | B | Inhibition of HDAC8 in C57BL/6 mouse embryonic fibroblasts assessed as induction of histone H3 hyperacetylation in promoter region of Nanog at 100 nM after 24 hrs by ChIP analysis | Mus musculus | 2 | ALA2396564 | single protein format | Scientific Literature | |
8. | ALA2400882 | B | Inhibition of HDAC8 in C57BL/6 mouse embryonic fibroblasts assessed as induction of histone H3 hyperacetylation in promoter region of Oct3/4 at 100 nM after 24 hrs by ChIP analysis | Mus musculus | 2 | ALA2396564 | single protein format | Scientific Literature | |
9. | ALA2401031 | F | Upregulation of Klf4 expression in C57BL/6 mouse embryonic fibroblasts at 100 nM after 24 hrs by qPCR analysis | Mus musculus | 2 | ALA2396564 | cell-based format | Scientific Literature | |
10. | ALA2401032 | A | Cytotoxicity against C57BL/6 mouse embryonic fibroblasts assessed as cell viability at 10 uM after 24 hrs by WST-8 assay | Mus musculus | 2 | ALA2396564 | cell-based format | Scientific Literature | |
11. | ALA2401033 | F | Upregulation of c-Myc expression in C57BL/6 mouse embryonic fibroblasts at 100 nM after 24 hrs by qPCR analysis | Mus musculus | 2 | ALA2396564 | cell-based format | Scientific Literature | |
12. | ALA2401034 | B | Inhibition of HDAC8 in C57BL/6 mouse embryonic fibroblasts assessed as upregulation of Dppa4 expression at 100 nM after 24 hrs by qPCR analysis relative to control | Mus musculus | 2 | ALA2396564 | assay format | Scientific Literature | |
13. | ALA2401035 | B | Inhibition of HDAC8 in C57BL/6 mouse embryonic fibroblasts assessed as upregulation of Cdh1 expression at 100 nM after 24 hrs by qPCR analysis relative to control | Mus musculus | 2 | ALA2396564 | assay format | Scientific Literature | |
14. | ALA2401036 | B | Inhibition of HDAC8 in C57BL/6 mouse embryonic fibroblasts assessed as upregulation of Rex1 expression at 100 nM after 24 hrs by qPCR analysis relative to control | Mus musculus | 2 | ALA2396564 | assay format | Scientific Literature | |
15. | ALA2401037 | B | Inhibition of HDAC8 in C57BL/6 mouse embryonic fibroblasts assessed as upregulation of Sox2 expression at 100 nM after 24 hrs by qPCR analysis relative to control | Mus musculus | 2 | ALA2396564 | assay format | Scientific Literature | |
16. | ALA2401038 | B | Inhibition of HDAC8 in C57BL/6 mouse embryonic fibroblasts assessed as upregulation of Nanog expression at 100 nM after 24 hrs by qPCR analysis relative to control | Mus musculus | 2 | ALA2396564 | assay format | Scientific Literature | |
17. | ALA2401039 | B | Inhibition of HDAC8 in C57BL/6 mouse embryonic fibroblasts assessed as upregulation of Oct3/4 expression at 100 nM after 24 hrs by qPCR analysis relative to control | Mus musculus | 2 | ALA2396564 | assay format | Scientific Literature | |
18. | ALA2401040 | B | Ratio of trichostatin A IC50 to compound IC50 for HDAC8 (unknown origin) | Homo sapiens | 1 | ALA2396564 | single protein format | Scientific Literature | |
19. | ALA2401041 | B | Inhibition of HDAC8 (unknown origin) after 30 mins by fluorometric analysis | Homo sapiens | 3 | ALA2396564 | single protein format | Scientific Literature | |
20. | ALA2401042 | B | Inhibition of HDAC1 (unknown origin) after 30 mins by fluorometric analysis | Homo sapiens | 3 | ALA2396564 | single protein format | Scientific Literature |