Antitumor activity against human SJSA1 cells xenografted in SCID mouse assessed as tumor growth inhibition at 100 mg/kg, po qd administered for 2 weeks measured after 10 days
Antitumor activity against human RS4:11 cells xenografted in mouse assessed as tumor regression at 200 mg/kg, po qd administered for 3 weeks measured after 26 days
Antitumor activity against human RS4:11 cells xenografted in mouse assessed as tumor growth inhibition at 100 mg/kg, po qd administered for 3 weeks measured after 4 days relative to vehicle-treated control
Antitumor activity against human RS4:11 cells xenografted in mouse assessed as tumor growth inhibition at 200 mg/kg, po qd administered for 3 weeks measured after 4 days relative to vehicle-treated control
Induction of apoptosis in human SJSA1 cells xenografted in SCID mouse assessed as caspase-3 cleavage at 100 mg/kg, po measured at 24 hrs by Western blot analysis
Induction of apoptosis in human SJSA1 cells xenografted in SCID mouse assessed as PARP cleavage at 100 mg/kg, po measured at 24 hrs by Western blot analysis
Induction of apoptosis in human SJSA1 cells xenografted in SCID mouse assessed as caspase-3 cleavage at 100 mg/kg, po measured at 1 to 6 hrs by Western blot analysis
Induction of apoptosis in human SJSA1 cells xenografted in SCID mouse assessed as PARP cleavage at 100 mg/kg, po measured at 1 to 6 hrs by Western blot analysis
Antitumor activity against human SJSA1 cells xenografted in SCID mouse assessed as upregulation of MDM2 expression in tumor at 100 mg/kg, po measured at 24 hrs by Western blot analysis
Antitumor activity against human SJSA1 cells xenografted in SCID mouse assessed as upregulation of p21 expression in tumor at 100 mg/kg, po measured at 24 hrs by Western blot analysis
Antitumor activity against human SJSA1 cells xenografted in SCID mouse assessed as upregulation of p53 expression in tumor at 100 mg/kg, po measured at 24 hrs by Western blot analysis
Antitumor activity against human SJSA1 cells xenografted in SCID mouse assessed as upregulation of MDM2 expression in tumor at 100 mg/kg, po measured at 3 to 6 hrs by Western blot analysis
Antitumor activity against human SJSA1 cells xenografted in SCID mouse assessed as upregulation of p21 expression in tumor at 100 mg/kg, po measured at 3 to 6 hrs by Western blot analysis
Antitumor activity against human SJSA1 cells xenografted in SCID mouse assessed as upregulation of p53 expression in tumor at 100 mg/kg, po measured at 3 to 6 hrs by Western blot analysis
Antitumor activity against human SJSA1 cells xenografted in SCID mouse assessed as tumor regression at 100 mg/kg, po qd administered for 2 weeks measured for 60 days
Antitumor activity against human SJSA1 cells xenografted in SCID mouse assessed as tumor growth inhibition at 100 mg/kg, po qd administered for 2 weeks measured after 5 days relative to vehicle-treated control