| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2400102 | F | Antitumor activity against human HCT116 cells xenografted in athymic nu/nu mouse assessed as reduction in tumor size at 20 mg/kg, iv bid for 5 days per week for 2 weeks measured twice a week | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA2400103 | F | Antitumor activity against human HCT116 cells xenografted in athymic nu/nu mouse assessed as reduction in tumor size at 50 mg/kg, iv qd for 5 days per week for 2 weeks measured twice a week | Homo sapiens | 2 | organism-based format | Scientific Literature | ||
| 3. | ALA2400105 | B | Inhibition of RAF1 (unknown origin) at 1 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 4. | ALA2400106 | B | Inhibition of FLT3 (unknown origin) at 1 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 5. | ALA2400107 | B | Inhibition of CHK2 (unknown origin) at 1 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 6. | ALA2400108 | B | Inhibition of NTRK1 (unknown origin) at 1 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA2400109 | B | Inhibition of Aurora kinase C (unknown origin) at 1 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 8. | ALA2400110 | B | Inhibition of Aurora kinase B (unknown origin) at 1 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA2400111 | B | Inhibition of Aurora kinase A (unknown origin) at 1 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA2400274 | B | Inhibition of Aurora kinase B in human HeLa cells assessed as delay in mitotic arrest by accumulation of multinucleated cells with 4N/8N DNA content at 10 to 1000 nM after 48 hrs by propidium iodide staining-based FACS flow cytometric analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA2400275 | B | Inhibition of Aurora kinase A in human HeLa cells assessed as delay in mitotic arrest by reformed nuclear envelope without cell division at 1 uM after 18 hrs by immunofluorescence staining based confocal microscopic analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA2400276 | B | Inhibition of Aurora kinase A in human HeLa cells assessed as delay in mitotic arrest by measuring flattened cells with decondensed chromosomes at 1 uM after 18 hrs by immunofluorescence staining based confocal microscopic analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA2400277 | B | Inhibition of Aurora kinase A in human HeLa cells assessed as mitotic arrest at >500 nM for 4 hrs by double thymidine block assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA2400280 | B | Inhibition of Aurora kinase A phosphorylation at Thr288 in human HCT116 cells at 4 to 1000 nM after 2 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA2400281 | B | Inhibition of Aurora kinase A phosphorylation at Thr288 in human HCT116 cells after 2 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA2400282 | B | Inhibition of Aurora kinase B-mediated histone H3 phosphorylation at Ser10 in human HCT116 cells at 4 to 1000 nM after 2 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA2400283 | B | Inhibition of Aurora kinase B-mediated histone H3 phosphorylation at Ser10 in human HCT116 cells after 2 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA2400284 | P | Aqueous solubility of the compound at 10 mg after 24 hrs by HPLC analysis | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 19. | ALA2400285 | B | Inhibition of human recombinant Aurora kinase B using tetra(LRRASLG) as substrate at 100 uM preincubated for 15 mins prior to substrate addition measured after 90 mins by luminescence assay relative to control | Homo sapiens | 12 | single protein format | Scientific Literature | ||
| 20. | ALA2400286 | B | Inhibition of human recombinant Aurora kinase B using tetra(LRRASLG) as substrate at 1 uM preincubated for 15 mins prior to substrate addition measured after 90 mins by luminescence assay relative to control | Homo sapiens | 13 | single protein format | Scientific Literature |
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