| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2400293 | P | Solubility of the compound in DMSO at 125 uM | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 2. | ALA2400294 | F | Antibacterial activity against Staphylococcus aureus ATCC 29213 expressing FabI assessed as growth inhibition after 18 to 24 hrs by microdilution method | Staphylococcus aureus | 4 | organism-based format | Scientific Literature | ||
| 3. | ALA2400295 | F | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 expressing FabI, FabV, FabK assessed as growth inhibition after 18 to 24 hrs by microdilution method | Pseudomonas aeruginosa | 4 | organism-based format | Scientific Literature | ||
| 4. | ALA2400296 | F | Antibacterial activity against Escherichia coli ATCC 25922 expressing FabI assessed as growth inhibition after 18 to 24 hrs by microdilution method | Escherichia coli | 4 | organism-based format | Scientific Literature | ||
| 5. | ALA2400297 | F | Antibacterial activity against Bacillus anthracis Ames expressing FabI assessed as growth inhibition after 18 to 24 hrs by microdilution method | Bacillus anthracis | 4 | organism-based format | Scientific Literature | ||
| 6. | ALA2400298 | F | Antibacterial activity against Francisella tularensis SCHU S4 expressing FabI assessed as growth inhibition after 42 to 48 hrs by microdilution method | Francisella tularensis subsp. tularensis SCHU S4 | 4 | organism-based format | Scientific Literature | ||
| 7. | ALA2400299 | A | Cytotoxicity against mouse Neuro2a cells assessed as cell survival after 72 hrs by CellTiter-96 aqueous one solution assay | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 8. | ALA2400300 | A | Cytotoxicity against human 786-O cells assessed as cell survival after 72 hrs by CellTiter-96 aqueous one solution assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 9. | ALA2400301 | B | Selectivity ratio of IC50 for C-terminal His6-tagged wild type Francisella tularensis SCHU S4 FabI to IC50 for Francisella tularensis SCHU S4 FabI R96M mutant | Francisella tularensis subsp. tularensis SCHU S4 | 4 | assay format | Scientific Literature | ||
| 10. | ALA2400302 | B | Selectivity ratio of IC50 for C-terminal His6-tagged wild type Francisella tularensis SCHU S4 FabI to IC50 for Francisella tularensis SCHU S4 FabI R96G mutant | Francisella tularensis subsp. tularensis SCHU S4 | 4 | assay format | Scientific Literature | ||
| 11. | ALA2400303 | B | Inhibition of Francisella tularensis SCHU S4 FabI F203L mutant using CrCoA as substrate by UV-vis spectrophotometric analysis in presence of non pre-equilibrated NAD+ | Francisella tularensis subsp. tularensis SCHU S4 | 4 | assay format | Scientific Literature | ||
| 12. | ALA2401002 | B | Inhibition of Francisella tularensis SCHU S4 FabI R96M mutant using CrCoA as substrate by UV-vis spectrophotometric analysis in presence of non pre-equilibrated NAD+ | Francisella tularensis subsp. tularensis SCHU S4 | 4 | assay format | Scientific Literature | ||
| 13. | ALA2401003 | B | Inhibition of Francisella tularensis SCHU S4 FabI R96G mutant using CrCoA as substrate by UV-vis spectrophotometric analysis in presence of non pre-equilibrated NAD+ | Francisella tularensis subsp. tularensis SCHU S4 | 4 | assay format | Scientific Literature | ||
| 14. | ALA2401004 | B | Inhibition of Francisella tularensis SCHU S4 FabI F93V mutant using CrCoA as substrate by UV-vis spectrophotometric analysis in presence of non pre-equilibrated NAD+ | Francisella tularensis subsp. tularensis SCHU S4 | 4 | assay format | Scientific Literature | ||
| 15. | ALA2401005 | B | Inhibition of C-terminal His6-tagged wild type Francisella tularensis SCHU S4 FabI expressed in Escherichia coli BL21 (DE3) using CrCoA as substrate by UV-vis spectrophotometric analysis in presence of non pre-equilibrated NAD+ | Francisella tularensis subsp. tularensis SCHU S4 | 4 | assay format | Scientific Literature | ||
| 16. | ALA2401007 | B | Competitive inhibition of C-terminal His6-tagged Francisella tularensis SCHU S4 FabI expressed in Escherichia coli BL21 (DE3) using CrCoA as substrate in presence of NAD+ | Francisella tularensis subsp. tularensis SCHU S4 | 2 | assay format | Scientific Literature | ||
| 17. | ALA2401008 | B | Selectivity ratio of IC50 for Francisella tularensis SCHU S4 FabI F93V mutant to IC50 for C-terminal His6-tagged wild type Francisella tularensis SCHU S4 FabI | Francisella tularensis subsp. tularensis SCHU S4 | 3 | assay format | Scientific Literature | ||
| 18. | ALA2401009 | B | Selectivity ratio of IC50 for Francisella tularensis SCHU S4 FabI F203L mutant to IC50 for C-terminal His6-tagged wild type Francisella tularensis SCHU S4 FabI | Francisella tularensis subsp. tularensis SCHU S4 | 2 | assay format | Scientific Literature |
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