# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2398836 | B | Inhibition of calcium channel (unknown origin) at 10 uM | Homo sapiens | 8 | ALA2396549 | assay format | Scientific Literature | |
2. | ALA2398837 | A | Metabolic stability in monkey liver microsomes assessed as compound remaining | Macaca mulatta | 9 | ALA2396549 | microsome format | Scientific Literature | |
3. | ALA2398838 | B | Inhibition of sodium channel (unknown origin) at 10 uM | Homo sapiens | 8 | ALA2396549 | assay format | Scientific Literature | |
4. | ALA2398839 | A | Metabolic stability in rat liver microsomes assessed as compound remaining | Rattus norvegicus | 10 | ALA2396549 | microsome format | Scientific Literature | |
5. | ALA2398840 | A | Metabolic stability in mouse liver microsomes assessed as compound remaining | Mus musculus | 10 | ALA2396549 | microsome format | Scientific Literature | |
6. | ALA2398841 | A | Metabolic stability in human liver microsomes assessed as compound remaining | Homo sapiens | 10 | ALA2396549 | microsome format | Scientific Literature | |
7. | ALA2398843 | B | Induction of PXR (unknown origin) | Homo sapiens | 12 | ALA2396549 | single protein format | Scientific Literature | |
8. | ALA2398869 | B | Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis | Homo sapiens | 33 | ALA2396549 | single protein format | Scientific Literature | |
9. | ALA2399021 | B | Binding affinity to human CCR1 | Homo sapiens | 57 | ALA2396549 | single protein format | Scientific Literature | |
10. | ALA3706150 | B | Binding Assay: For radioligand competition studies, a final concentration of 1x105 THP-1 monocytic leukemia cells are combined with 100 μg of LS WGA PS beads (Amersham, Cat.#: RPNQ 0260) in 40 μL of assay buffer (RPMI 1640 without phenol red, 50 mM HEPES, 5 mM MgCl2, 1 mM CaCl2, 0.1% BSA). The THP-1 cell/bead mixture was added to each well of a 384-well assay plate (PerkinElmer, Cat. #:6007899) containing test compound in 3-fold serial dilution, with final concentrations ranging from 8 μM to 0.14 nM. A final concentration of 0.1 nM [125I]-MIP-1α (PerkinElmer, Cat. #NEX298) in 20 μL assay buffer was added to the reaction. Unlabeled MIP-1α was added in excess to some wells to determine non-specific binding. Sealed assay plates were incubated at room temperature for 12 h then analyzed by LEADseeker. | Homo sapiens | 5 | ALA3638549 | cell-based format | BindingDB Database |