# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2399637 | B | Selectivity index, ratio of IC50 for ACAT1 (unknown origin) to IC50 for ACAT2 (unknown origin) | Homo sapiens | 31 | ALA2396612 | assay format | Scientific Literature | |
2. | ALA2399638 | B | Inhibition of ACAT1 (unknown origin) | Homo sapiens | 31 | ALA2396612 | single protein format | Scientific Literature | |
3. | ALA2399639 | B | Inhibition of ACAT2 (unknown origin) | Homo sapiens | 31 | ALA2396612 | single protein format | Scientific Literature | |
4. | ALA3880968 | A | Half life in Sprague-Dawley rat liver microsomes at 6 ug/ml by HPLC method | Rattus norvegicus | 41 | ALA3880418 | tissue-based format | Patent Bioactivity Data | |
5. | ALA3880969 | B | Inhibition of ACAT2 in mouse hepatic microsomal membranes assessed as decrease in formation of [14C]cholesteryl oleate from [1,14C]oleoyl co-enzyme A after 5 mins by bio-image analyzer | Mus musculus | 35 | ALA3880418 | cell membrane format | Patent Bioactivity Data | |
6. | ALA3880970 | B | Ratio of compound IC50 to PRD 043 IC50 for ACAT2 in mouse hepatic microsomal membranes | Mus musculus | 35 | ALA3880418 | cell membrane format | Patent Bioactivity Data | |
7. | ALA4418324 | B | Inhibition of ACAT2 in mouse hepatic microsome membranes using [1-14C]oleoyl coenzyme A as substrate incubated for 5 mins | Mus musculus | 35 | ALA4418261 | microsome format | Patent Bioactivity Data | |
8. | ALA4418325 | B | Potency index, ratio of PRD-043 IC50 to test compound IC50 for inhibition ACAT2 in mouse hepatic microsome membranes using [1-14C]oleoyl coenzyme A as substrate incubated for 5 mins | Mus musculus | 35 | ALA4418261 | microsome format | Patent Bioactivity Data | |
9. | ALA4418326 | A | Half life in Sprague-Dawley rat hepatic microsomes at 6 ug/ml by LC-MS method | Rattus norvegicus | 41 | ALA4418261 | microsome format | Patent Bioactivity Data | |
10. | ALA5243740 | B | Selectivity index, ratio of IC50 for SOAT1 (unknown origin) to IC50 for SOAT2 (unknown origin) | 18 | ALA5241121 | assay format | Scientific Literature | ||
11. | ALA5243742 | B | Inhibition of SOAT1 (unknown origin) expressed in CHO cells using [14C]oleic acid incubated for 6 hrs | Homo sapiens | 21 | ALA5241121 | cell-based format | Scientific Literature | |
12. | ALA5243743 | B | Inhibition of SOAT2 (unknown origin) expressed in CHO cells using [14C]oleic acid incubated for 6 hrs | Homo sapiens | 21 | ALA5241121 | cell-based format | Scientific Literature |