# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2405592 | B | Inhibition of 11beta-HSD2 in human kidney microsomes using [3H]-cortisol as substrate assessed as formation of cortisone at 100 uM after 30 mins by radiometric analysis relative to control | Homo sapiens | 36 | microsome format | Scientific Literature | ||
2. | ALA2405593 | B | Inhibition of 11beta-HSD2 in rat kidney microsomes using [3H]-CORT as substrate assessed as formation of 11-DHC at 100 uM after 30 mins by radiometric analysis relative to control | Rattus norvegicus | 36 | microsome format | Scientific Literature | ||
3. | ALA2405597 | B | Inhibition of human 11beta-HSD1 transfected in CHOP cells at 100 uM relative to control | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
4. | ALA2405599 | B | Inhibition of 11beta-HSD1 in Sprague-Dawley rat leydig cells at 100 uM relative to control | Rattus norvegicus | 21 | assay format | Scientific Literature | ||
5. | ALA2405604 | B | Inhibition of 11beta-HSD1 in rat testis microsomes using [3H]-11-DHC as substrate assessed as formation of CORT at 100 uM after 60 to 90 mins by radiometric analysis relative to control | Rattus norvegicus | 27 | microsome format | Scientific Literature | ||
6. | ALA2405606 | B | Inhibition of 11beta-HSD1 in human liver microsomes using [3H]-cortisone as substrate assessed as formation of cortisol at 100 uM after 60 to 90 mins by radiometric analysis relative to control | Homo sapiens | 26 | microsome format | Scientific Literature | ||
7. | ALA4152768 | A | Toxicity in zebra fish larvae at 5 uM after 48 hrs | Danio rerio | 72 | organism-based format | Scientific Literature | ||
8. | ALA4152770 | A | Cytotoxicity against mouse 3T3L1 cells at 50 uM after 24 hrs by sulforhodamine B assay | Mus musculus | 72 | cell-based format | Scientific Literature | ||
9. | ALA4152771 | A | Cytotoxicity against mouse 3T3L1 cells at 50 uM after 48 hrs by sulforhodamine B assay | Mus musculus | 72 | cell-based format | Scientific Literature | ||
10. | ALA4152774 | F | Lipid lowering activity in zebrafish embryos at 5 uM by Nile red fat metabolism assay | Danio rerio | 39 | organism-based format | Scientific Literature |