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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA2403916 Functional Ex vivo NK1 receptor occupancy in rhesus monkey brain assessed as concentration required for 90% occupancy at 67 nM plasma concentration by PET imaging analysis Macaca mulatta 2 ALA2401672 organism-based format Scientific Literature 2. ALA2403917 ADME Time dependent inhibition of human CYP3A4 at 10 uM Homo sapiens 1 ALA2401672 single protein format Scientific Literature 3. ALA2403918 Binding Agonist activity at human PXR at 3.4 uM relative to rifampicin Homo sapiens 1 ALA2401672 single protein format Scientific Literature 4. ALA2403919 ADME Inhibition of human CYP2C9 Homo sapiens 1 ALA2401672 single protein format Scientific Literature 5. ALA2403920 ADME Inhibition of human CYP2D6 Homo sapiens 1 ALA2401672 single protein format Scientific Literature 6. ALA2403921 ADME Inhibition of human CYP3A4 Homo sapiens 1 ALA2401672 single protein format Scientific Literature 7. ALA2403922 ADME Inhibition of human CYP2C8 Homo sapiens 1 ALA2401672 single protein format Scientific Literature 8. ALA2403923 ADME Metabolic stability in human hepatocytes assessed as compound remaining at 1 uM after 24 hrs Homo sapiens 1 ALA2401672 cell-based format Scientific Literature 9. ALA2403924 ADME Oral bioavailability in dog 1 mg/kg Canis lupus familiaris 2 ALA2401672 organism-based format Scientific Literature 10. ALA2403925 ADME Oral bioavailability in monkey 1 mg/kg Macaca mulatta 2 ALA2401672 organism-based format Scientific Literature 11. ALA2403926 ADME Drug metabolism in human hepatocytes assessed as glucuronic acid conjugate formation at 1 uM after 24 hrs Homo sapiens 1 ALA2401672 cell-based format Scientific Literature 12. ALA2403927 ADME Oral bioavailability in rat at 2 mg/kg Rattus norvegicus 2 ALA2401672 organism-based format Scientific Literature 13. ALA2403928 ADME Half life in dog at 0.5 mg/kg, iv and 1 mg/kg, po Canis lupus familiaris 2 ALA2401672 organism-based format Scientific Literature 14. ALA2403929 ADME Half life in monkey at 0.5 mg/kg, iv and 1 mg/kg, po Macaca mulatta 2 ALA2401672 organism-based format Scientific Literature 15. ALA2403930 ADME Half life in rat at 1 mg/kg, iv and 2 mg/kg, po Rattus norvegicus 2 ALA2401672 organism-based format Scientific Literature 16. ALA2403931 ADME Volume of distribution at steady state in monkey at 0.5 mg/kg, iv and 1 mg/kg, po Macaca mulatta 2 ALA2401672 organism-based format Scientific Literature 17. ALA2403932 ADME Volume of distribution at steady state in rat at 1 mg/kg, iv and 2 mg/kg, po Rattus norvegicus 2 ALA2401672 organism-based format Scientific Literature 18. ALA2403933 ADME Volume of distribution at steady state in dog at 0.5 mg/kg, iv and 1 mg/kg, po Canis lupus familiaris 2 ALA2401672 organism-based format Scientific Literature 19. ALA2403934 ADME Plasma clearance in monkey at 0.5 mg/kg, iv and 1 mg/kg, po Macaca mulatta 2 ALA2401672 organism-based format Scientific Literature 20. ALA2403935 ADME Plasma clearance in rat at 1 mg/kg, iv and 2 mg/kg, po Rattus norvegicus 2 ALA2401672 organism-based format Scientific Literature