# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2406708 | Functional | Inhibition of human osteoclast-mediated type 1 bone collagen degradation assessed as release of europium-labeled collagen fragments at 0.1 uM after 7 days by time-resolved fluorescence assay | Homo sapiens | 3 | ALA2401628 | cell-based format | Scientific Literature | |
2. | ALA2406709 | Functional | Inhibition of human osteoclast-mediated type 1 bone collagen degradation assessed as release of europium-labeled collagen fragments at 10 uM after 7 days by time-resolved fluorescence assay | Homo sapiens | 2 | ALA2401628 | cell-based format | Scientific Literature | |
3. | ALA2406710 | Functional | Proapoptotic activity in human osteoclasts at 10 uM after 7 days using Hoechst 33258 staining | Homo sapiens | 3 | ALA2401628 | cell-based format | Scientific Literature | |
4. | ALA2406711 | Functional | Induction of apoptosis in human osteoclasts at 100 uM after 7 days using Hoechst 33258 staining | Homo sapiens | 3 | ALA2401628 | cell-based format | Scientific Literature | |
5. | ALA2406712 | Functional | Antiosteoclast activity in human PBMC assessed as reduction of osteoclasts formation by measuring TRAcP positive multinucleated cells at 10 uM after 7 days | Homo sapiens | 6 | ALA2401628 | cell-based format | Scientific Literature | |
6. | ALA2406713 | ADME | Cytotoxicity against mouse L929 cells assessed as reduction of cell viability at 100 uM after 72 hrs by neutral-red uptake assay | Mus musculus | 4 | ALA2401628 | cell-based format | Scientific Literature | |
7. | ALA2406715 | ADME | Cytotoxicity against mouse L929 cells assessed as reduction of cell viability at 10 to 100 uM after 72 hrs by neutral-red uptake assay | Mus musculus | 4 | ALA2401628 | cell-based format | Scientific Literature | |
8. | ALA2406716 | Binding | Binding affinity to hydroxyapatite at 0.07 mmol up to 120 hrs by 31P NMR-spectroscopy relative to H3PO4 | Not specified | 6 | ALA2401628 | assay format | Scientific Literature |