# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2405841 | A | Inhibition of CYP3A4 in human liver microsomes assessed as midazolam hydroxylation to 1'-Hydroxymidazolam after 7 mins by LC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
2. | ALA2405842 | A | Inhibition of CYP2C19 in human liver microsomes assessed as (S)-Mephenytoin hydroxylation to 4'-Hydroxymephenytoin after 30 mins by LC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
3. | ALA2405843 | A | Inhibition of CYP2D6 in human liver microsomes assessed as dextrometorphan O-demethylation to dextrorphan after 30 mins by LC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
4. | ALA2405844 | A | Inhibition of CYP2C9 in human liver microsomes assessed as tolbutamide hdroxylation to 4-Hydroxytolbutamide after 50 mins by LC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
5. | ALA2405845 | A | Inhibition of CYP1A2 in human liver microsomes assessed as phenacetin O-deethylation to acetaminophen after 30 mins by LC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature | ||
6. | ALA2405846 | F | Growth inhibition of human MPNST cells at 0.001 to 10 uM after 72 hrs by SRB assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
7. | ALA2405847 | F | Growth inhibition of human LPS141 cells at 0.001 to 10 uM after 72 hrs by SRB assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
8. | ALA2405848 | F | Growth inhibition of human LMS676 cells at 0.001 to 10 uM after 72 hrs by SRB assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
9. | ALA2405855 | F | Growth inhibition of human MPNST cells after 72 hrs by SRB assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA2405856 | F | Growth inhibition of human LMS676 cells after 72 hrs by SRB assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
11. | ALA2405857 | F | Growth inhibition of human LPS141 cells after 72 hrs by SRB assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
12. | ALA2405858 | B | Inhibition of BCR/ABL T315I mutant in human BAF3 cells assessed as growth inhibition after 72 hrs by luminescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
13. | ALA2405859 | B | Inhibition of BCR/ABL in human BAF3 cells assessed as growth inhibition after 72 hrs by luminescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
14. | ALA2405861 | B | Inhibition of KIT in human GISTT1 cells assessed as decrease in total protein level at 70 nM after 24 hrs by Western blotting analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
15. | ALA2406052 | B | Inhibition of KIT T760I mutant phosphorylation at Tyr703 in human GISTT1 cells at 400 nM after 24 hrs by Western blotting analysis relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
16. | ALA2406053 | B | Inhibition of KIT T760I mutant phosphorylation at Tyr703 in human GISTT1 cells at 35 nM after 24 hrs by Western blotting analysis relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
17. | ALA2406054 | B | Inhibition of KIT-mediated MAPK phosphorylation at Thr202 and Tyr204 in human GISTT1 cells after 24 hrs by Western blotting analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
18. | ALA2406055 | B | Inhibition of KIT-mediated Akt phosphorylation at Ser473 in human GISTT1 cells after 24 hrs by Western blotting analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
19. | ALA2406056 | B | Inhibition of KIT phosphorylation at Tyr703 in human GISTT1 cells after 24 hrs by Western blotting analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
20. | ALA2406058 | A | Growth inhibition of human GIST48B cells after 72 hrs by SRB assay | Homo sapiens | 5 | cell-based format | Scientific Literature |