Inhibition of K+ depolarization-induced [3H]D-aspartate efflux in Sprague-Dawley rat synaptosome preincubated at 50 uM for 8 mins by liquid scintillation counting
Antagonist activity at P2X7 in Sprague-Dawley rat synaptosome assessed as inhibition of BzATP-induced [3H]D-aspartate efflux preincubated at 50 uM for 8 mins by liquid scintillation counting in absence of extracellular Ca2+
Antagonist activity at P2X7 in Sprague-Dawley rat synaptosome assessed as inhibition of BzATP-induced [3H]D-aspartate efflux preincubated at 50 uM for 8 mins by liquid scintillation counting
Antagonist activity at P2X7 in Sprague-Dawley rat synaptosome assessed as inhibition of BzATP-induced [3H]D-aspartate efflux compound preincubated for 8 mins by liquid scintillation counting
Agonist activity at P2X7 in Sprague-Dawley rat synaptosome assessed as [3H]D-aspartate efflux preincubated at 10 to 50 uM for 8 mins by liquid scintillation counting
Antinociceptive activity against carrageenan-induced paw edema in rat assessed as paw edema volume at 20 mg/kg, po measured after 30 mins (Rvb = 2.71+/- 0.08 ml)
Antinociceptive activity against carrageenan-induced paw edema in rat assessed as paw edema volume at 10 mg/kg, po measured after 30 mins (Rvb = 2.71+/- 0.08 ml)
Antinociceptive activity against carrageenan-induced paw edema in rat assessed as paw edema volume at 3 mg/kg, po measured after 30 mins (Rvb = 2.71+/- 0.08 ml)
Antinociceptive activity against carrageenan-induced hyperalgesia in rat assessed as paw pressure at 20 mg/kg, po measured after 90 mins (Rvb = 34.8 +/- 3.1 g)
Antinociceptive activity against carrageenan-induced hyperalgesia in rat assessed as paw pressure at 10 mg/kg, po measured after 90 mins (Rvb = 34.8 +/- 3.1 g)
Antinociceptive activity against carrageenan-induced hyperalgesia in rat assessed as paw pressure at 3 mg/kg, po measured after 90 mins (Rvb = 34.8 +/- 3.1 g)
Antinociceptive activity against carrageenan-induced hyperalgesia in rat assessed as paw pressure at 20 mg/kg, po measured after 60 mins (Rvb = 31.8 +/- 2.2 g)
Antinociceptive activity against carrageenan-induced hyperalgesia in rat assessed as paw pressure at 10 mg/kg, po measured after 60 mins (Rvb = 31.8 +/- 2.2 g)
Antinociceptive activity against carrageenan-induced hyperalgesia in rat assessed as paw pressure at 3 mg/kg, po measured after 60 mins (Rvb = 31.8 +/- 2.2 g)
Antinociceptive activity against carrageenan-induced hyperalgesia in rat assessed as paw pressure at 20 mg/kg, po measured after 30 mins (Rvb = 30.6 +/- 3.2 g)
Antinociceptive activity against carrageenan-induced hyperalgesia in rat assessed as paw pressure at 10 mg/kg, po measured after 30 mins (Rvb = 30.6 +/- 3.2 g)
Antinociceptive activity against carrageenan-induced hyperalgesia in rat assessed as paw pressure at 3 mg/kg, po measured after 30 mins (Rvb = 30.6 +/- 3.2 g)
Antinociceptive activity against carrageenan-induced hyperalgesia in rat assessed as paw pressure at 20 mg/kg, po measured after 15 mins (Rvb = 32.8 +/- 2.9 g)