| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2410101 | T | Toxicity in human MDA-MB-468 cells xenografted CB-17 SCID mouse assessed as reduction in body weight at 25 mg/kg, ip qd for 21 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA2410102 | F | Antitumor activity against human MDA-MB-468 cells xenografted in CB-17 SCID mouse assessed as reduction in tumor regression at 50 mg/kg, ip qd for 21 days | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA2410103 | F | Antitumor activity against human MDA-MB-468 cells xenografted in CB-17 SCID mouse assessed as reduction in tumor size at 50 mg/kg, ip qd for 21 days | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA2410104 | F | Antitumor activity against human MDA-MB-468 cells xenografted in CB-17 SCID mouse assessed as reduction in tumor size at 25 mg/kg, ip qd for 21 days relative to control | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA2410105 | A | AUC in SCID mouse at 50 mg/kg, ip | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA2410106 | A | Plasma protein binding in mouse at 10 mM after 4 hrs by equilibrium dialysis method | Mus musculus | 1 | cell-free format | Scientific Literature | ||
| 7. | ALA2410107 | A | Cmax in SCID mouse at 50 mg/kg, ip | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA2410108 | B | Selectivity ratio of IC50 for KDR (unknown origin) to IC50 for N-terminal GST-tagged human PLK4 (1 to 391 amino acids) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 9. | ALA2410109 | B | Selectivity ratio of IC50 for Aurora B (unknown origin) to IC50 for N-terminal GST-tagged human PLK4 (1 to 391 amino acids) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 10. | ALA2410110 | B | Selectivity ratio of IC50 for FLT3 (unknown origin) to IC50 for N-terminal GST-tagged human PLK4 (1 to 391 amino acids) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 11. | ALA2410111 | B | Selectivity ratio of IC50 for Aurora A (unknown origin) to IC50 for N-terminal GST-tagged human PLK4 (1 to 391 amino acids) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 12. | ALA2410112 | B | Inhibition of KDR (unknown origin) by FRET-based homogeneous assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA2410113 | B | Inhibition of aurora B (unknown origin) by FRET-based homogeneous assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA2410114 | B | Inhibition of FLT3 (unknown origin) by FRET-based homogeneous assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 15. | ALA2410115 | B | Inhibition of aurora A (unknown origin) by FRET-based homogeneous assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 16. | ALA2410116 | A | Permeability of the compound at pH 7.4 by PAMPA | 6 | assay format | Scientific Literature | |||
| 17. | ALA2410117 | A | Inhibition of CYP2C9 (unknown origin) using MFC as substrate after 45 mins by fluorescence assay | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 18. | ALA2410118 | A | Inhibition of CYP2C19 (unknown origin) using MFC as substrate after 30 mins by fluorescence assay | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 19. | ALA2410119 | A | Inhibition of CYP1A2 (unknown origin) using CEC as substrate after 15 mins by fluorescence assay | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 20. | ALA2410120 | A | Inhibition of CYP2D6 (unknown origin) using AMMC as substrate after 30 mins by fluorescence assay | Homo sapiens | 6 | single protein format | Scientific Literature |
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