# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2412374 | F | Effect on total ATP level in human Friedreich's ataxia lymphocytes at 25 uM after 48 hrs by bioluminescence assay relative to control | Homo sapiens | 10 | ALA2406929 | assay format | Scientific Literature | |
2. | ALA2412375 | F | Effect on total ATP level in human Friedreich's ataxia lymphocytes at 10 uM after 48 hrs by bioluminescence assay relative to control | Homo sapiens | 10 | ALA2406929 | assay format | Scientific Literature | |
3. | ALA2412376 | F | Effect on total ATP level in human Friedreich's ataxia lymphocytes at 5 uM after 48 hrs by bioluminescence assay relative to control | Homo sapiens | 10 | ALA2406929 | assay format | Scientific Literature | |
4. | ALA2412377 | F | Reversal of 4-nitrobenzoate-induced reduction in mitochondrial ATP level in CoQ10-deficient human Friedreich's ataxia lymphocytes at 5 uM after 6 days by bioluminescence assay | Homo sapiens | 2 | ALA2406929 | assay format | Scientific Literature | |
5. | ALA2412378 | F | Effect on total ATP level in CoQ10-deficient human GM17932 cells at 25 uM after 48 hrs by bioluminescence assay relative to control | Homo sapiens | 10 | ALA2406929 | assay format | Scientific Literature | |
6. | ALA2412379 | F | Effect on total ATP level in CoQ10-deficient human GM17932 cells at 10 uM after 48 hrs by bioluminescence assay relative to control | Homo sapiens | 10 | ALA2406929 | assay format | Scientific Literature | |
7. | ALA2412380 | F | Effect on total ATP level in CoQ10-deficient human GM17932 cells at 5 uM after 48 hrs by bioluminescence assay relative to control | Homo sapiens | 10 | ALA2406929 | assay format | Scientific Literature | |
8. | ALA2412381 | F | Cytoprotective activity against BSO-induced cell death in human Friedreich's ataxia lymphocytes preincubated for 12 hrs prior to BSO-treatment measured after 48 hrs by luminescence assay | Homo sapiens | 9 | ALA2406929 | assay format | Scientific Literature | |
9. | ALA2412382 | F | Cytoprotective activity against diethyl maleate-induced loss of mitochondrial membrane integrity in human Friedreich's ataxia lymphocytes at 500 nM incubated overnight prior to diethyl maleate-treatment measured after 140 mins by TMRM staining-based FACS flow cytometric analysis relative to control | Homo sapiens | 9 | ALA2406929 | assay format | Scientific Literature | |
10. | ALA2412383 | F | Cytoprotective activity against diethyl maleate-induced loss of mitochondrial membrane integrity in human Friedreich's ataxia lymphocytes at 250 nM incubated overnight prior to diethyl maleate-treatment measured after 140 mins by TMRM staining-based FACS flow cytometric analysis relative to control | Homo sapiens | 9 | ALA2406929 | assay format | Scientific Literature | |
11. | ALA2412384 | F | Cytoprotective activity against diethyl maleate-induced loss of mitochondrial membrane integrity in human Friedreich's ataxia lymphocytes at 100 nM incubated overnight prior to diethyl maleate-treatment measured after 140 mins by TMRM staining-based FACS flow cytometric analysis relative to control | Homo sapiens | 9 | ALA2406929 | assay format | Scientific Literature | |
12. | ALA2412385 | F | Antioxidant activity in human Friedreich's ataxia lymphocytes assessed as inhibition of diethyl maleate-induced lipid peroxidation at 100 to 500 nM incubated overnight prior to diethyl maleate-treatment measured after 120 mins by C11-BODIPY581/591 staining-based FACS flow cytometric analysis | Homo sapiens | 5 | ALA2406929 | assay format | Scientific Literature | |
13. | ALA4430888 | F | Antioxidant activity in FRDA patient derived lymphocyte GM15850 assessed as inhibition of DEM-induced lipid peroxidation at 0.1 to 1 uM pre-incubated for 16 hrs followed by DEM addition for 120 mins by C11-BODIPY581/591 probe based flow cytometry relative to control | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
14. | ALA4430890 | F | Antioxidant activity in FRDA patient derived lymphocyte GM15850 assessed as suppression of DEM-induced intracellular ROS levels at 100 nM pre-incubated for 16 hrs followed by DEM addition for 80 mins by DCFH-DA probe based flow cytometry | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
15. | ALA4430892 | F | Inhibition of DEM-induced collapse of mitochondrial membrane potential in FRDA patient derived lymphocyte GM15850 assessed as intact mitochondrial membrane potential at 100 nM pre-incubated for 16 hrs followed by DEM addition for 120 mins by TMRM dye based flow cytometry (Rvb = 91.3 %) | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
16. | ALA4430893 | F | Inhibition of DEM-induced collapse of mitochondrial membrane potential in FRDA patient derived lymphocyte GM15850 assessed as intact mitochondrial membrane potential at 1000 nM pre-incubated for 16 hrs followed by DEM addition for 120 mins by TMRM dye based flow cytometry (Rvb = 91.3 %) | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
17. | ALA4430894 | F | Inhibition of DEM-induced collapse of mitochondrial membrane potential in FRDA patient derived lymphocyte GM15850 assessed as intact mitochondrial membrane potential at 2500 nM pre-incubated for 16 hrs followed by DEM addition for 120 mins by TMRM dye based flow cytometry (Rvb = 91.3 %) | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
18. | ALA4430895 | F | Inhibition of DEM-induced collapse of mitochondrial membrane potential in FRDA patient derived lymphocyte GM15850 assessed as intact mitochondrial membrane potential pre-incubated for 16 hrs followed by DEM addition for 120 mins by TMRM dye based flow cytometry | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
19. | ALA4430896 | A | Effect on mitochondrial membrane potential in FRDA patient derived lymphocyte GM15850 incubated for 16 hrs by TMRM dye based flow cytometry | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature | |
20. | ALA4430897 | F | Increase in total intracellular ATP levels in FRDA patient derived lymphocyte GM15850 grown in galactose medium at 1 uM after 48 hrs by luciferin-luciferase reaction based bioluminescence assay relative to control | Homo sapiens | 9 | ALA4428118 | cell-based format | Scientific Literature |