# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2411839 | A | Prodrug conversion in sodium phosphate buffer at pH 7.4 assessed as CYP2W1 (unknown origin)-mediated formation of active spirocyclized CPI-MI preincubated for 3 mins at 25 to 50 uM by LC-MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
2. | ALA2411841 | A | Potentiation factor, ratio of IC50 for wild type HEK293 cells to IC50 of HEK293 cells expressing CYP1A1 | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
3. | ALA2411843 | F | Antiproliferative activity against human RT112 cells expressing CYP1A1 assessed as growth inhibition after 96 hrs by MTT assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
4. | ALA2411844 | A | Antiproliferative activity against CHO cells assessed as growth inhibition after 96 hrs by MTT assay | Cricetulus griseus | 12 | cell-based format | Scientific Literature | ||
5. | ALA2411845 | F | Antiproliferative activity against CHO cells expressing CYP1A1 assessed as growth inhibition after 96 hrs by MTT assay | Cricetulus griseus | 12 | cell-based format | Scientific Literature | ||
6. | ALA2411846 | A | Potentiation factor, ratio of IC50 for wild type CHO cells to IC50 of CHO cells expressing CYP1A1 | Cricetulus griseus | 11 | cell-based format | Scientific Literature | ||
7. | ALA2411847 | A | Antiproliferative activity against human HEK293 cells assessed as growth inhibition after 96 hrs by MTT assay | Cricetulus griseus | 12 | cell-based format | Scientific Literature | ||
8. | ALA2411848 | F | Antiproliferative activity against human HEK293 cells expressing CYP2W1 assessed as growth inhibition after 96 hrs by MTT assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
9. | ALA2411849 | F | Induction of DNA damage in human RT112 cells assessed as phosphorylation of gammaH2A.X at 0.5 to 5 uM after 48 hrs by Western blotting analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
10. | ALA2412008 | F | Induction of DNA damage in human HEK293 cells expressing CYP2W1 assessed as phosphorylation of gammaH2A.X at 0.5 to 5 uM after 48 hrs by Western blotting analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
11. | ALA2412009 | A | Induction of DNA damage in mock-transfected human HEK293 assessed as phosphorylation of gammaH2A.X at 0.5 to 5 uM after 48 hrs by Western blotting analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
12. | ALA2412012 | F | Induction of cell death in human RT112 cells after 48 hrs at 0.5 to 5 uM by trypan blue assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
13. | ALA2412013 | A | Induction of cell death in mock-transfected human HEK293 cells t 0.5 to 5 uM after 48 hrs by trypan blue assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
14. | ALA2412014 | F | Induction of cell death in human HEK293 cells expressing CYP2W1 t 0.5 to 5 uM after 48 hrs by trypan blue assay | Homo sapiens | 3 | cell-based format | Scientific Literature |