# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2423076 | B | Binding affinity to human GFP-tagged NPC1L1 L1072T/L1168I mutant expressed in HEK293 cells assessed as localization to endoplasmic reticulum and plasma membrane after 24 hrs by fluorescence microscopic analysis | Homo sapiens | 27 | ALA2417499 | cell-based format | Scientific Literature | |
2. | ALA3362444 | B | Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization at 10 uM after 24 hrs by fluorescence microscopy | Homo sapiens | 14 | ALA3352343 | cell-based format | Scientific Literature | |
3. | ALA4408248 | B | Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamate-induced channel current at -70 mV holding potential by IonWork two-electrode voltage clamp method | Homo sapiens | 27 | ALA4406822 | cell-based format | Scientific Literature | |
4. | ALA4408249 | B | Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamate-induced channel current at -70 mV holding potential by IonWork two-electrode voltage clamp method relative to control | Homo sapiens | 19 | ALA4406822 | cell-based format | Scientific Literature | |
5. | ALA4408250 | B | Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamate-induced channel current at -70 mV holding potential by IonWork two-electrode voltage clamp method | Homo sapiens | 27 | ALA4406822 | cell-based format | Scientific Literature | |
6. | ALA4408251 | B | Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamate-induced channel current at -70 mV holding potential by IonWork two-electrode voltage clamp method relative to control | Homo sapiens | 21 | ALA4406822 | cell-based format | Scientific Literature | |
7. | ALA4408260 | A | Stability in human liver microsomes | Homo sapiens | 23 | ALA4406822 | microsome format | Scientific Literature | |
8. | ALA4408261 | A | Stability in rat liver microsomes | Rattus norvegicus | 23 | ALA4406822 | microsome format | Scientific Literature | |
9. | ALA4408268 | F | Induction of synaptic plasticity in postnatal 60 to 90 day rat brain hippocampal slice assessed as change in theta burst stimulaiton-induced field potential potentiation at 1 uM treated 20 mins prior to theta burst stimulation by electrophysiological method | Rattus norvegicus | 1 | ALA4406822 | tissue-based format | Scientific Literature | |
10. | ALA4408269 | F | Induction of synaptic plasticity in postnatal 120 to 150 day rat brain hippocampal slice assessed as stimulation of theta burst stimulaiton-induced field potential potentiation at 1 uM treated 20 mins prior to theta burst stimulation and measured after 60 mins by electrophysiological method | Rattus norvegicus | 2 | ALA4406822 | tissue-based format | Scientific Literature |