# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2423163 | F | Cytotoxicity against human A2780 cells after 72 hrs by sulforhodamine B assay in presence of NMN | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
2. | ALA2423348 | P | Aqueous solubility of the compound in PBS buffer at 100 uM after 24 hrs at pH 7.4 by LC/CLND analysis | 36 | small-molecule physicochemical format | Scientific Literature | |||
3. | ALA2423349 | B | Inhibition of human NAMPT using NAM/PRPP as substrate incubated for 15 mins prior to substrate addition measured after 30 mins by mass spectrometric analysis | Homo sapiens | 36 | single protein format | Scientific Literature | ||
4. | ALA2423350 | F | Cytotoxicity against human A2780 cells after 72 hrs by sulforhodamine B assay | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
5. | ALA2423677 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM after 30 mins LC-MS analysis | Homo sapiens | 59 | microsome format | Scientific Literature | ||
6. | ALA2423678 | A | Metabolic stability in mouse liver microsomes assessed as compound remaining at 1 uM after 30 mins LC-MS analysis | Mus musculus | 59 | microsome format | Scientific Literature | ||
7. | ALA2423679 | F | Antiproliferative activity against human A2780 cells assessed as growth inhibition after 72 hrs by SRB-based microplate reader analysis | Homo sapiens | 60 | cell-based format | Scientific Literature | ||
8. | ALA2423680 | B | Inhibition of C-terminal His-tagged NAMPT (unknown origin) expressed in Escherichia coli BL21 using nicotinamide as substrate preincubated for 15 mins before substrate addition measured after 30 mins by mass spectrometry-based assay | Homo sapiens | 60 | assay format | Scientific Literature | ||
9. | ALA3396926 | B | Inhibition of human C-terminal His6-tagged NAMPT expressed in Escherichia coli Rosetta(DE3) incubated for 15 mins prior to substrate addition measured after 30 mins | Homo sapiens | 33 | assay format | Scientific Literature | ||
10. | ALA3396927 | F | Antiproliferative activity against human A2780 cells after 72 hrs by SRB method | Homo sapiens | 33 | cell-based format | Scientific Literature | ||
11. | ALA3396930 | P | Kinetic solubility of the compound in aqueous buffer at pH 7.4 after 24 hrs | 34 | small-molecule physicochemical format | Scientific Literature | |||
12. | ALA3396932 | A | Apparent permeability from apical to basolateral side in MDCK cells | Canis lupus familiaris | 33 | cell-based format | Scientific Literature | ||
13. | ALA3396933 | A | Apparent permeability from basolateral to apical side in MDCK cells | Canis lupus familiaris | 33 | cell-based format | Scientific Literature | ||
14. | ALA3395050 | F | Antiproliferative activity against human A2780 cells after 72 hrs by SRB method in presence on NMN | Homo sapiens | 33 | cell-based format | Scientific Literature | ||
15. | ALA3867189 | B | Inhibition of human full length C-terminal His6-tagged NAMPT expressed in Escherichia coli Rosetta (DE3) cells using nicotinamide as substrate incubated for 15 mins prior to substrate addition measured after 30 mins in presence of PRPP | Homo sapiens | 69 | cell-based format | Scientific Literature | ||
16. | ALA3867190 | B | Inhibition of NAMPT in human A2780 cells assessed as decrease in cell viability after 72 hrs by SRB assay | Homo sapiens | 63 | cell-based format | Scientific Literature | ||
17. | ALA3867191 | A | Reversible inhibition of CYP2C9 in human liver microsomes using (S)-warfarin as substrate in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 67 | tissue-based format | Scientific Literature | ||
18. | ALA3867198 | A | Time dependent inhibition of CYP3A4 in human liver microsomes assessed as substrate AUC shift using testosterone as substrate | Homo sapiens | 9 | tissue-based format | Scientific Literature | ||
19. | ALA3867199 | A | Time dependent inhibition of CYP3A4 in human liver microsomes assessed as substrate AUC shift using midazolam as substrate | Homo sapiens | 9 | tissue-based format | Scientific Literature |