# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2422484 | A | Cytotoxicity against human HepG2 cells assessed as inhibition of cell viability at 50 uM after 48 hrs by SRB assay relative to vehicle-treated control | Homo sapiens | 3 | ALA2417463 | cell-based format | Scientific Literature | |
2. | ALA2422485 | A | Cytotoxicity against mouse BV2 cells assessed as inhibition of cell viability at 50 uM after 48 hrs by SRB assay relative to vehicle-treated control | Mus musculus | 3 | ALA2417463 | cell-based format | Scientific Literature | |
3. | ALA2422486 | A | Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell viability at 50 uM after 48 hrs by SRB assay relative to vehicle-treated control | Mus musculus | 3 | ALA2417463 | cell-based format | Scientific Literature | |
4. | ALA2422487 | A | Induction of cytoplasmic lipid accumulation in human HepG2 cells at 10 uM after 4 days by oil red O staining-based light microscopic analysis | Homo sapiens | 3 | ALA2417463 | cell-based format | Scientific Literature | |
5. | ALA2422489 | A | Induction of intracellular triglyceride accumulation in human HepG2 cells at 10 uM after 4 days relative to vehicle-treated control | Homo sapiens | 4 | ALA2417463 | cell-based format | Scientific Literature | |
6. | ALA2422490 | A | Induction of intracellular triglyceride accumulation in human HepG2 cells at 1 uM after 4 days relative to vehicle-treated control | Homo sapiens | 5 | ALA2417463 | cell-based format | Scientific Literature | |
7. | ALA2422719 | B | Agonist activity at LXRbeta in mouse BV2 cells assessed as degradation of intracellular soluble amyloid beta42 at 1 uM preincubated for 18 hrs followed by soluble amyloid beta42 addition measured after 24 hrs by ELISA relative to vehicle-treated control | Mus musculus | 13 | ALA2417463 | cell-based format | Scientific Literature | |
8. | ALA2422721 | B | Agonist activity at LXRbeta in mouse BV2 cells assessed as upregulation of apoE protein expression at 1 uM after 48 hrs by Western blot analysis relative to vehicle-treated control | Mus musculus | 3 | ALA2417463 | cell-based format | Scientific Literature | |
9. | ALA2422722 | B | Agonist activity at LXRbeta in mouse BV2 cells assessed as upregulation of apoE protein expression at 0.1 uM after 48 hrs by Western blot analysis relative to vehicle-treated control | Mus musculus | 3 | ALA2417463 | cell-based format | Scientific Literature | |
10. | ALA2422723 | B | Agonist activity at LXRbeta in mouse BV2 cells assessed as upregulation of ABCA1 protein expression after 12 to 48 hrs by Western blot analysis | Mus musculus | 3 | ALA2417463 | cell-based format | Scientific Literature | |
11. | ALA2422724 | B | Agonist activity at LXRbeta in mouse BV2 cells assessed as upregulation of ABCA1 protein expression at 1 uM after 12 to 48 hrs by Western blot analysis | Mus musculus | 3 | ALA2417463 | cell-based format | Scientific Literature | |
12. | ALA2422725 | B | Agonist activity at LXRbeta in mouse RAW264.7 cells assessed as upregulation of ABCA1 protein expression after 18 to 48 hrs by Western blot analysis | Mus musculus | 3 | ALA2417463 | cell-based format | Scientific Literature | |
13. | ALA2422726 | B | Agonist activity at LXRbeta in mouse RAW264.7 cells assessed as upregulation of ABCA1 protein expression at 1 uM after 18 to 48 hrs by Western blot analysis | Mus musculus | 3 | ALA2417463 | cell-based format | Scientific Literature | |
14. | ALA2422727 | B | Agonist activity at human LXRbeta transfected in HEK293 cells at 1 uM after 24 hrs by luciferase reporter gene assay relative to vehicle-treated control | Homo sapiens | 4 | ALA2417463 | cell-based format | Scientific Literature | |
15. | ALA2421018 | B | Agonist activity at human LXRbeta transfected in HEK293 cells at 0.1 uM after 24 hrs by luciferase reporter gene assay relative to vehicle-treated control | Homo sapiens | 4 | ALA2417463 | cell-based format | Scientific Literature | |
16. | ALA2421019 | B | Agonist activity at human LXRalpha transfected in HEK293 cells at 1 uM after 24 hrs by luciferase reporter gene assay relative to vehicle-treated control | Homo sapiens | 4 | ALA2417463 | cell-based format | Scientific Literature | |
17. | ALA2421020 | B | Agonist activity at human LXRalpha transfected in HEK293 cells at 0.1 uM after 24 hrs by luciferase reporter gene assay relative to vehicle-treated control | Homo sapiens | 4 | ALA2417463 | cell-based format | Scientific Literature | |
18. | ALA2421022 | B | Agonist activity at LXRbeta in mouse RAW264.7 cells assessed as induction of ABCA1 promoter activation at 1 uM after 24 hrs by Dual-Glo luciferase reporter gene assay relative to vehicle-treated control | Mus musculus | 45 | ALA2417463 | cell-based format | Scientific Literature | |
19. | ALA2421023 | A | Cytotoxicity against HEK293 cells assessed as inhibition of cell viability at 50 uM after 48 hrs by SRB assay relative to vehicle-treated control | Homo sapiens | 3 | ALA2417463 | cell-based format | Scientific Literature | |
20. | ALA4182523 | F | Up-regulation of ABCA1 protein expression in serum of Wistar rat model of metabolic syndrome fed with high-sugar-fat-diet for 15 weeks followed by high-fat emulsion for 2 weeks by ELISA | Rattus norvegicus | 41 | ALA4177718 | organism-based format | Scientific Literature |