# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2423208 | B | Inhibition of Trypanosoma cruzi cruzain expressed in Escherichia coli DH5-alpha using Bz-Phe-Arg-AMC as substrate at 10 uM preincubated for 5 mins followed by substrate addition measured for 5 mins by spectrofluorimetric analysis relative to control | Trypanosoma cruzi | 13 | assay format | Scientific Literature | ||
2. | ALA2423383 | F | Trypanocidal activity against epimastigote stage of Trypanosoma cruzi Y after 72 hrs by MTT assay | Trypanosoma cruzi | 13 | organism-based format | Scientific Literature | ||
3. | ALA3412104 | B | Inhibition of mushroom tyrosinase diphenolase activity using L-DOPA as substrate preincubated for 30 mins followed by substrate addition measured for 1 min | Agaricus bisporus | 26 | single protein format | Scientific Literature | ||
4. | ALA4196378 | F | Antitrypanosomal activity against Trypanosoma brucei Lister 427 bloodstream form assessed as parasite growth inhibition at 50 uM after 72 hrs by SYBR Green assay relative to control | Trypanosoma brucei | 28 | organism-based format | Scientific Literature | ||
5. | ALA4196379 | F | Antileishmanial activity against Leishmania infantum amastigote form assessed as parasite growth inhibition at 50 uM after 72 hrs by steady-Glo reagent based assay relative to control | Leishmania infantum | 28 | organism-based format | Scientific Literature | ||
6. | ALA4196380 | F | Antitrypanosomal activity against Trypanosoma cruzi amastigote form infected in human U2OS cells assessed as parasite growth inhibition at 50 uM after 72 hrs relative to control | Trypanosoma cruzi | 42 | organism-based format | Scientific Literature | ||
7. | ALA4196384 | F | Antitrypanosomal activity against Trypanosoma brucei Lister 427 bloodstream form at 10 uM after 72 hrs by resazurin dye-based assay relative to control | Trypanosoma brucei | 28 | organism-based format | Scientific Literature | ||
8. | ALA4196385 | F | Potentiation of methotrexate-induced antitrypanosomal activity against Trypanosoma brucei Lister 427 bloodstream form at 10 uM after 72 hrs by resazurin dye-based assay relative to control | Trypanosoma brucei | 28 | organism-based format | Scientific Literature | ||
9. | ALA4196386 | A | Inhibition of human microsomal CYP1A2 expressed in baculovirus infected BTI-TN-5B1-4 cells at 10 uM incubated for 30 mins by luciferase assay relative to control | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
10. | ALA4196387 | F | Potentiation of methotrexate-induced antitrypanosomal activity against Trypanosoma brucei Lister 427 bloodstream form at 10 uM after 72 hrs by resazurin dye-based assay | Trypanosoma brucei | 28 | organism-based format | Scientific Literature | ||
11. | ALA4196392 | B | Inhibition of human ERG at 10 uM incubated for 2 hrs by fluorescence polarisation assay relative to control | Homo sapiens | 28 | single protein format | Scientific Literature | ||
12. | ALA4196393 | A | Inhibition of human microsomal CYP2C9 expressed in baculovirus infected BTI-TN-5B1-4 cells at 10 uM incubated for 30 mins by luciferase assay relative to control | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
13. | ALA4196394 | A | Inhibition of human microsomal CYP2C19 expressed in baculovirus infected BTI-TN-5B1-4 cells at 10 uM incubated for 30 mins by luciferase assay relative to control | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
14. | ALA4196395 | A | Inhibition of human microsomal CYP2D6 expressed in baculovirus infected BTI-TN-5B1-4 cells at 10 uM incubated for 30 mins by luciferase assay relative to control | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
15. | ALA4196396 | A | Inhibition of human microsomal CYP3A4 expressed in baculovirus infected BTI-TN-5B1-4 cells at 10 uM incubated for 30 mins by luciferase assay relative to control | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
16. | ALA4196397 | A | Inhibition of recombinant full-length human aurora B kinase expressed in baculovirus system at 10 uM using MBP as substrate incubated for 45 mins by ADP-glo kinase assay | Homo sapiens | 28 | assay format | Scientific Literature | ||
17. | ALA4196398 | A | Cytotoxicity against human A549 cells assessed as growth inhibition at 10 uM after 48 hrs by CellTiter-Glo assay relative to control | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
18. | ALA4196399 | A | Cytotoxicity against human WI38 cells assessed as growth inhibition at 10 uM after 48 hrs by CellTiter-Glo assay relative to control | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
19. | ALA4196400 | A | Cytotoxicity against human 786-O cells assessed as inhibition of mitochondrial viability at 10 uM after 6 hrs by CMXRos staining based assay relative to control | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
20. | ALA4196401 | A | Cytotoxicity against human THP1 cells assessed as viable cells at 100 uM after 72 hrs by MTT assay relative to control | Homo sapiens | 28 | cell-based format | Scientific Literature |