| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2427612 | F | In vivo inhibition of extracellular cyclophilin-mediated monocytes recruitment in peritoneal fluid in thioglycollate challenged CD147-deficient C57BL6 mouse peritonitis model at 20 mg/kg, ip administered 3 hrs before thioglycollate challenge measured after 18 hrs | Mus musculus | 1 | ALA2424541 | organism-based format | Scientific Literature | |
| 2. | ALA2427613 | A | Cellular uptake in human Jurkat T cells assessed as displacemnet of [O-(2-acetamido)-D-serine]8-cyclosporine N-{(5-aminopentyl)-[2,3,6,7-tetrahydro-11-oxo-1H,5H,11Hbenzopyrano(6,7,8-ij)quinolizine-10-carboxyl amide] from intracellular compartments at 50 fold excess after 90 mins by flow cytometric analysis | Homo sapiens | 1 | ALA2424541 | cell-based format | Scientific Literature | |
| 3. | ALA2427615 | F | In vivo inhibition of extracellular cyclophilin-mediated CD3+ T cells infiltration into TNCB challenged ear in CD147-deficient C57BL6 mouse allergic contact hypersensitivity model at 4 mg/kg, ip bid administered on day 4 to 6 prior to TNCB challenge by immunohistochemical analysis | Mus musculus | 1 | ALA2424541 | organism-based format | Scientific Literature | |
| 4. | ALA2427616 | F | In vivo inhibition of extracellular cyclophilin-mediated CD11b+ myeloid cells infiltration into TNCB challenged ear in CD147-deficient C57BL6 mouse allergic contact hypersensitivity model at 4 mg/kg, ip bid administered on day 4 to 6 prior to TNCB challenge by immunohistochemical analysis | Mus musculus | 1 | ALA2424541 | organism-based format | Scientific Literature | |
| 5. | ALA2427617 | F | In vivo inhibition of extracellular cyclophilin-mediated ear swelling in CD147-deficient TNCB challenged C57BL6 mouse at 4 mg/kg, ip bid administered on day 4 to 6 | Mus musculus | 1 | ALA2424541 | organism-based format | Scientific Literature | |
| 6. | ALA2427618 | F | In vivo inhibition of extracellular cyclophilin-mediated neutrophil recruitment in peritoneal fluid in thioglycollate challenged CD147-deficient C57BL6 mouse peritonitis model at 20 mg/kg, ip administered 3 hrs before thioglycollate challenge measured after 18 hrs | Mus musculus | 1 | ALA2424541 | organism-based format | Scientific Literature | |
| 7. | ALA2427619 | B | Inhibition of recombinant human CypA-mediated CD147-deficient leukocyte migration from mouse bone marrow at 1 uM after 2 hrs | Homo sapiens | 1 | ALA2424541 | single protein format | Scientific Literature | |
| 8. | ALA2427620 | F | Effect on fmlp-induced CD147-deficient mouse leukocytes migration from bone marrow | Mus musculus | 1 | ALA2424541 | assay format | Scientific Literature | |
| 9. | ALA2427621 | F | Effect on FCS-induced CD147-deficient mouse leukocytes migration from bone marrow | Mus musculus | 1 | ALA2424541 | assay format | Scientific Literature | |
| 10. | ALA2427622 | F | Effect on fmlp-induced wild type mouse leukocytes migration from bone marrow | Mus musculus | 1 | ALA2424541 | assay format | Scientific Literature | |
| 11. | ALA2427623 | F | Effect on FCS-induced wild type mouse leukocytes migration from bone marrow | Mus musculus | 1 | ALA2424541 | assay format | Scientific Literature | |
| 12. | ALA2427624 | B | Inhibition of recombinant human CypA-mediated leukocyte migration from mouse bone marrow after 2 hrs | Homo sapiens | 1 | ALA2424541 | single protein format | Scientific Literature | |
| 13. | ALA2427625 | B | Inhibition of recombinant human CypA-mediated PMA/ionomycin-induced CD3+ T cell migration from mouse spleen at 1 uM after 2 hrs | Homo sapiens | 1 | ALA2424541 | single protein format | Scientific Literature | |
| 14. | ALA2427626 | B | Inhibition of recombinant human CypA-mediated CD11b+ myeloid cell migration from mouse bone marrow at 1 uM after 2 hrs | Homo sapiens | 1 | ALA2424541 | single protein format | Scientific Literature | |
| 15. | ALA2427809 | B | Inhibition of recombinant human CypA-mediated leukocyte migration from mouse bone marrow at 1 uM after 2 hrs | Homo sapiens | 1 | ALA2424541 | single protein format | Scientific Literature | |
| 16. | ALA2427810 | B | Inhibition of CypA-mediated ERK phosphorylation in serum-starved human HeLa cells at 2 uM after 5 mins by Western blotting analysis | Homo sapiens | 1 | ALA2424541 | cell-based format | Scientific Literature | |
| 17. | ALA2427811 | F | In vivo inhibition of extracellular cyclophilin-mediated CD11b+ myeloid cells infiltration into TNCB challenged ear in C57BL6 mouse allergic contact hypersensitivity model at 4 mg/kg, ip bid administered on day 4 to 6 prior to TNCB challenge by immunohistochemical analysis | Mus musculus | 1 | ALA2424541 | organism-based format | Scientific Literature | |
| 18. | ALA2427812 | F | In vivo inhibition of extracellular cyclophilin-mediated ear swelling in TNCB challenged C57BL6 mouse allergic contact hypersensitivity model at 4 mg/kg, ip bid administered on day 4 to 6 measured after 24 hrs | Mus musculus | 1 | ALA2424541 | organism-based format | Scientific Literature | |
| 19. | ALA2427813 | F | In vivo inhibition of extracellular cyclophilin-mediated MMP-9 secretion in peritoneal fluid in thioglycollate challenged C57BL6 mouse peritonitis model at 20 mg/kg, ip administered for 3 hrs before thioglycollate challenge by gelatin zymographic analysis | Mus musculus | 1 | ALA2424541 | organism-based format | Scientific Literature | |
| 20. | ALA2428066 | F | In vivo inhibition of extracellular cyclophilin-mediated IL-6 secretion in peritoneal fluid in thioglycollate challenged C57BL6 mouse peritonitis model at 20 mg/kg, ip administered for 3 hrs before thioglycollate challenge by ELISA | Mus musculus | 1 | ALA2424541 | organism-based format | Scientific Literature |
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