| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2427937 | B | Inhibition of recombinant human DNA topoisomerase 2-alpha assessed as supression of kDNA decatenation at 100 uM after 30 mins by agarose gel electrophoresis | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 2. | ALA2427939 | B | Inhibition of calf thymus DNA topoisomerase 1-mediated relaxation of supercoiled pBR322 DNA at 100 uM after 30 mins by Agarose gel electrophoresis | Bos taurus | 9 | assay format | Scientific Literature | ||
| 3. | ALA2427940 | B | Induction of DNA intercalation activity of calf thymus DNA topoisomerase 1 assessed as unwinding of pBR322 DNA up to 100 uM after 30 mins by Agarose gel electrophoresis | Bos taurus | 1 | nucleic acid format | Scientific Literature | ||
| 4. | ALA2427944 | B | Induction of recombinant human DNA topoisomerase 2-alpha poisoning activity using pBR322 as substrate assessed as appearance of linear DNA at 100 uM after 30 mins by Agarose gel electrophoresis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 5. | ALA2427945 | B | Induction of calf thymus DNA topoisomerase 1 poisoning activity using pBR322 as substrate assessed as appearance of nicked open circular DNA at 100 uM after 30 mins by Agarose gel electrophoresis | Bos taurus | 1 | assay format | Scientific Literature | ||
| 6. | ALA2427946 | B | Inhibition of recombinant human DNA topoisomerase 2-alpha-mediated relaxation of supercoiled pBR322 DNA at 10 to 100 uM after 30 mins by Agarose gel electrophoresis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA2427947 | B | Inhibition of calf thymus DNA topoisomerase 1-mediated relaxation of supercoiled pBR322 DNA at 10 to 100 uM after 30 mins by Agarose gel electrophoresis | Bos taurus | 1 | assay format | Scientific Literature | ||
| 8. | ALA2427948 | F | Induction of apoptosis in human MDA-MB-435 cells at 0.25 to 1 uM after 24 hrs by annexin-V FITC/propidium iodide staining-based flow cytometry in presence of N-acetylcysteine | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA2427949 | F | Cell cycle arrest in human MDA-MB-435 cells at 0.25 to 1 uM after 24 hrs by propidium iodide staining-based flow cytometry in presence of N-acetylcysteine | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA2427950 | F | Induction of human apoptosis in MDA-MB-435 cells assessed as upregulation of Bak protein expression at 0.25 to 1 uM after 12 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA2427951 | F | Induction of apoptosis in human MDA-MB-435 cells assessed as PARP cleavage after 12 to 24 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA2427952 | F | Induction of apoptosis in human MDA-MB-435 cells assessed as increase in cleaved-caspase 3 expression after 12 to 24 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA2429443 | F | Induction of apoptosis in human MDA-MB-435 cells assessed as decrease in procaspase 3 expression after 12 to 24 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA2429444 | F | Induction of apoptosis in human MDA-MB-435 cells assessed as dead cells at 2 uM after 24 hrs by annexin-V FITC/propidium iodide staining-based flow cytometry (Rvb = 0.61 +/- 0.24%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA2429445 | F | Induction of apoptosis in human MDA-MB-435 cells assessed as late apoptotic cells at 2 uM after 24 hrs by annexin-V FITC/propidium iodide staining-based flow cytometry (Rvb = 0.34 +/- 0.08%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA2429446 | F | Induction of apoptosis in human MDA-MB-435 cells assessed as early apoptotic cells at 2 uM after 24 hrs by annexin-V FITC/propidium iodide staining-based flow cytometry (Rvb = 0.61 +/- 0.24%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA2429447 | F | Induction of apoptosis in human MDA-MB-435 cells assessed as viable cells at 2 uM after 24 hrs by annexin-V FITC/propidium iodide staining-based flow cytometry (Rvb = 98.62 +/- 0.25%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA2429448 | F | Induction of apoptosis in human MDA-MB-435 cells assessed as dead cells at 1 uM after 24 hrs by annexin-V FITC/propidium iodide staining-based flow cytometry (Rvb = 0.61 +/- 0.24%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA2427526 | F | Induction of apoptosis in human MDA-MB-435 cells assessed as late apoptotic cells at 1 uM after 24 hrs by annexin-V FITC/propidium iodide staining-based flow cytometry (Rvb = 0.34 +/- 0.08%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA2427527 | F | Induction of apoptosis in human MDA-MB-435 cells assessed as early apoptotic cells at 1 uM after 24 hrs by annexin-V FITC/propidium iodide staining-based flow cytometry (Rvb = 0.61 +/- 0.24%) | Homo sapiens | 1 | cell-based format | Scientific Literature |
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