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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA2426870 A Prodrug activation in APP51/16 transgenic male mouse blood assessed as (1R,3R,4S,5S)-3-Amino-5-[4-amino-3-fluoro-5-((R)-2,2,2-trifluoro-1-methoxymethyl-ethoxy)-benzyl]-1-oxo-tetrahydro-thiopyran-4-ol level at 60 umol/kg, po after 4 hrs Mus musculus 3 organism-based format Scientific Literature 2. ALA2427016 F Antialzheimer activity in APP51/16 transgenic male mouse assessed as reduction of amyloid beta 40 level in brain at 60 umol/kg, po after 4 hrs Mus musculus 3 organism-based format Scientific Literature 3. ALA2427018 A Fraction unbound in APP51/16 transgenic male mouse brain at 60 umol/kg, po after 4 hrs Mus musculus 1 organism-based format Scientific Literature 4. ALA2427024 A Drug level in APP51/16 transgenic male mouse brain at 60 umol/kg, po after 4 hrs Mus musculus 3 organism-based format Scientific Literature 5. ALA2427031 A Prodrug activation in APP51/16 transgenic male mouse blood assessed as (1R,3S,4S,5R)-3-(4-Amino-3-fluoro-5-hydroxy-benzyl)-5-(3-tert-butyl-benzylamino)-1-oxo-tetrahydro-thiopyran-4-ol level at 60 umol/kg, po after 4 hrs Mus musculus 3 organism-based format Scientific Literature 6. ALA2427037 A Drug level in APP51/16 transgenic male mouse blood at 60 umol/kg, po after 4 hrs Mus musculus 3 organism-based format Scientific Literature 7. ALA2427039 A Clearance in mouse liver microsomes Mus musculus 14 microsome format Scientific Literature 8. ALA2427040 A Clearance in human liver microsomes Homo sapiens 14 microsome format Scientific Literature 9. ALA2427043 A Inhibition of CYP3A4 (unknown origin) Homo sapiens 18 single protein format Scientific Literature 10. ALA2427044 P Lipophilicity, log P of the compound 18 small-molecule physicochemical format Scientific Literature 11. ALA2427046 A Efflux ratio of permeability from apical to basolateral side over basolateral to apical side in MDCK2 cells expressing human MDR1 Canis lupus familiaris 20 cell-based format Scientific Literature 12. ALA2427047 A Apparent permeability of the compound in MDCK cells expressing human MDR1 Canis lupus familiaris 20 cell-based format Scientific Literature 13. ALA2427049 B Inhibition of BACE1 (unknown origin) expressed in CHO cells co-expressing wild type APP Homo sapiens 20 cell-based format Scientific Literature 14. ALA2427050 B Inhibition of human cathepsin-D Homo sapiens 20 single protein format Scientific Literature 15. ALA2427051 B Inhibition of human BACE1 Homo sapiens 22 single protein format Scientific Literature