Toxicity in athymic nude mouse xenografted in human MDA-MB-231 cells assessed as mortality at 50 mg/kg, ip bid administered every other day started on day 14 followed by compound readministration every other day started on day 27
Toxicity in athymic nude mouse xenografted in human MDA-MB-231 cells assessed as mortality at 75 mg/kg, ip qd administered every other day started on day 14 for 5 days followed by compound readministration on day 27
Toxicity in athymic nude mouse xenografted in human MDA-MB-231 cells assessed as mortality at 75 mg/kg, ip qd administered on day 14 for 5 days followed by compound readministration on day 27
Toxicity in athymic nude mouse xenografted in human MDA-MB-231 cells assessed as mortality at 50 mg/kg, ip qd administered on day 14 for 5 days followed by compound readministration on day 27
Antitumor activity against human MDA-MB-231 cells xenografted in athymic nude mouse assessed as delay in tumor growth at 50 mg/kg, ip bid administered every other day started on day 14 followed by compound readministration every other day started on day 27 measured on day 31 relative to control
Antitumor activity against human MDA-MB-231 cells xenografted in athymic nude mouse assessed as delay in tumor growth at 75 mg/kg, ip qd administered every other day started on day 14 for 5 days followed by compound readministration on day 27 measured on day 31 relative to control
Antitumor activity against human MDA-MB-231 cells xenografted in athymic nude mouse assessed as delay in tumor growth at 75 mg/kg, ip qd administered on day 14 for 5 days followed by compound readministration on day 27 measured on day 31 relative to control
Antitumor activity against human MDA-MB-231 cells xenografted in athymic nude mouse assessed as delay in tumor growth at 50 mg/kg, ip qd administered on day 14 for 5 days followed by compound readministration on day 27 measured on day 31 relative to control
Antitumor activity against human MDA-MB-231 cells xenografted in athymic nude mouse assessed as tumor growth inhibition at 50 mg/kg, ip bid administered every other day started on day 14 followed by compound readministration every other day started on day 27 measured on day 31 relative to control
Antitumor activity against human MDA-MB-231 cells xenografted in athymic nude mouse assessed as tumor growth inhibition at 75 mg/kg, ip qd administered every other day started on day 14 for 5 days followed by compound readministration on day 27 measured on day 31 relative to control
Antitumor activity against human MDA-MB-231 cells xenografted in athymic nude mouse assessed as tumor growth inhibition at 75 mg/kg, ip qd administered on day 14 for 5 days followed by compound readministration on day 27 measured on day 31 relative to control
Antitumor activity against human MDA-MB-231 cells xenografted in athymic nude mouse assessed as tumor growth inhibition at 50 mg/kg, ip qd administered on day 14 for 5 days followed by compound readministration on day 27 measured on day 31 relative to control
Toxicity in athymic nude mouse xenografted in human MDA-MB-231 cells assessed as body weight loss at 50 mg/kg, ip bid administered every other day started on day 14 followed by compound readministration every other day started on day 27 (Rvb = 6.7%)
Toxicity in athymic nude mouse xenografted in human MDA-MB-231 cells assessed as body weight loss at 75 mg/kg, ip qd administered every other day started on day 14 for 5 days followed by compound readministration on day 27 (Rvb = 6.7%)
Toxicity in athymic nude mouse xenografted in human MDA-MB-231 cells assessed as body weight loss at 75 mg/kg, ip qd administered on day 14 for 5 days followed by compound readministration on day 27 (Rvb = 6.7%)
Toxicity in athymic nude mouse xenografted in human MDA-MB-231 cells assessed as body weight loss at 50 mg/kg, ip qd administered on day 14 for 5 days followed by compound readministration on day 27 (Rvb = 6.7%)
Antitumor activity against human MDA-MB-231 cells xenografted in athymic nude mouse assessed as tumor free state at 50 mg/kg, ip bid administered every other day started on day 14 followed by compound readministration every other day started on day 27 measured on day 41
Antitumor activity against human MDA-MB-231 cells xenografted in athymic nude mouse assessed as tumor free state at 75 mg/kg, ip qd administered every other day started on day 14 for 5 days followed by compound readministration on day 27 measured on day 41
Antitumor activity against human MDA-MB-231 cells xenografted in athymic nude mouse assessed as tumor free state at 75 mg/kg, ip qd administered on day 14 for 5 days followed by compound readministration on day 27 measured on day 41
Antitumor activity against human MDA-MB-231 cells xenografted in athymic nude mouse assessed as tumor free state at 50 mg/kg, ip qd administered on day 14 for 5 days followed by compound readministration on day 27 measured on day 41