Agonist activity at Pseudomonas aeruginosa PA14 PqsR expressed in Eschericia coli DH5-alpha at 50 nM by beta-galactosidase reporter gene assay relative to control
Antibacterial activity against Pseudomonas aeruginosa PAO397 [PAO1 d(mexAB-oprM) d(mexCD-oprJ) d(mexEF-oprN) d(mexJKL) d(mexXY) d(opmH)] (CO-ADD:GN_211); MIC in CAMBH media using NBS plates, by OD(600)
Neuroprotective activity against glutamate-induced cytotoxicity in mouse HT-22 cells assessed as increase in cell viability at 0.6 uM in presence of glutamate by calcein-AM dye/propidium iodide staining based microscopic analysis
Neuroprotective activity against glutamate-induced cytotoxicity in mouse HT-22 cells assessed as increase in cell viability at 1.85 to 5.5 uM in presence of glutamate by calcein-AM dye/propidium iodide staining based microscopic analysis
Inhibition of glutamate-induced oxidative stress in mouse HT-22 cells assessed as reduction in intracellular ROS accumulation at 0.2 to 1.8 uM in presence of glutamate by FACS analysis
Inhibition of glutamate-induced oxidative stress in mouse HT-22 cells assessed as reduction in intracellular ROS accumulation at 0.2 to 3.6 uM in presence of glutamate by DCF-DA staining based fluorescence microscopic analysis
Inhibition of glutamate-induced Ca2+ influx in mouse HT-22 cells assessed as reduction in intracellular Ca2+ concentration in presence of glutamate by Fluo3-AM staining based fluorescence microscopic method
Inhibition of glutamate-induced JNK activation in mouse HT-22 cells assessed as reduction in phosphorylated JNK protein level at 1 to 10 uM in presence of glutamate by Western blot analysis