# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2427500 | B | Inhibition of Cryptosporidium hominis thymidylate synthase | Cryptosporidium hominis | 6 | assay format | Scientific Literature | ||
2. | ALA3106434 | F | Cytotoxicity against human KB cells expressing human RFC/FRalpha/PCFT after 96 hrs by CellTitre-Blue fluorescence assay in presence of folic acid | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
3. | ALA3106435 | F | Cytotoxicity against human KB cells expressing human RFC/FRalpha/PCFT after 96 hrs by CellTitre-Blue fluorescence assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
4. | ALA3106436 | F | Cytotoxicity against chinese hamster R2(VC) cells after 96 hrs by CellTitre-Blue fluorescence assay | Cricetulus griseus | 13 | cell-based format | Scientific Literature | ||
5. | ALA3106437 | F | Cytotoxicity against chinese hamster R2 cells expressing human PCFT4 after 96 hrs by CellTitre-Blue fluorescence assay | Cricetulus griseus | 13 | cell-based format | Scientific Literature | ||
6. | ALA3106438 | F | Cytotoxicity against chinese hamster RT16 cells expressing human FRalpha after 96 hrs by CellTitre-Blue fluorescence assay | Cricetulus griseus | 6 | cell-based format | Scientific Literature | ||
7. | ALA3106439 | F | Cytotoxicity against chinese hamster RT16 cells expressing human FRalpha after 96 hrs by CellTitre-Blue fluorescence assay in presence of folic acid | Cricetulus griseus | 6 | cell-based format | Scientific Literature | ||
8. | ALA3106440 | F | Cytotoxicity against chinese hamster R2 cells after 96 hrs by CellTitre-Blue fluorescence assay | Cricetulus griseus | 7 | cell-based format | Scientific Literature | ||
9. | ALA3106441 | F | Cytotoxicity against chinese hamster PC43-10 cells expressing human RFC after 96 hrs by CellTitre-Blue fluorescence assay | Cricetulus griseus | 7 | cell-based format | Scientific Literature | ||
10. | ALA3364301 | B | Inhibition of thymidylate synthase activity of Cryptosporidium hominis bifunctional dihydrofolate reductase-thymidylate synthase assessed as reduction in conversion of dUMP and CH2H4F to products dTMP and H2F | Cryptosporidium hominis | 1 | single protein format | Scientific Literature | ||
11. | ALA3364302 | B | Selectivity index, ratio of IC50 for human thymidylate synthase to IC50 for thymidylate synthase activity of Cryptosporidium hominis bifunctional dihydrofolate reductase-thymidylate synthase | 1 | assay format | Scientific Literature | |||
12. | ALA3364303 | B | Inhibition of human thymidylate synthase | Homo sapiens | 1 | single protein format | Scientific Literature | ||
13. | ALA3364304 | B | Inhibition of DHFR activity of Cryptosporidium hominis bifunctional dihydrofolate reductase-thymidylate synthase assessed as reduction in NADPH oxidation to NAD | Cryptosporidium hominis | 1 | single protein format | Scientific Literature | ||
14. | ALA3364305 | B | Inhibition of human DHFR | Homo sapiens | 1 | single protein format | Scientific Literature | ||
15. | ALA3364306 | F | Antiparasitic activity against compound pre-treated Cryptosporidium hominis Iowa sporozoites infected in human HCT8 cells assessed as reduction in parasite infection | Cryptosporidium hominis | 1 | organism-based format | Scientific Literature | ||
16. | ALA3364307 | T | Toxicity in Cryptosporidium hominis Iowa sporozoites infected human HCT8 cells assessed as effect on cell viability by microscopy | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
17. | ALA3364308 | T | Toxicity in Cryptosporidium hominis Iowa sporozoites infected human HCT8 cells assessed as effect on RNA levels | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
18. | ALA3364309 | T | Toxicity in Cryptosporidium hominis Iowa sporozoites infected human HCT8 cells assessed as effect on cell morphology by microscopy | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
19. | ALA3364310 | F | Antiparasitic activity against Cryptosporidium hominis Iowa intracellular forms infected in human HCT8 cells assessed as reduction in parasite infection dosed 2 hrs after parasite infection | Cryptosporidium hominis | 1 | organism-based format | Scientific Literature |