| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA715661 | F | Compound was evaluated for the blood-schizonticidal antimalarial activity against Plasmodium berghei (sensitive strain) in mice (Mus musculus) at 10 mg/kg/day x 4 (oral); indicates that all of the treated animals show negative parasitaemia up to D+7 (survival=4/6) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA878350 | F | Compound was evaluated for the blood-schizonticidal antimalarial activity against Plasmodium berghei (sensitive strain) in mice (Mus musculus) at 100 mg/kg/day x 4 (oral); indicates complete elimination of malaria parasites from the body, and animals survive up to day D+ 60 (survival=6/6) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA716859 | F | Compound was evaluated for the blood-schizonticidal antimalarial activity against Plasmodium berghei (sensitive strain) in mice (Mus musculus) at 25 mg/kg/day x 4 (oral); indicates complete elimination of malaria parasites from the body, and animals survive up to day D+6 0 (survival=6/6) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA716860 | F | Compound was evaluated for the blood-schizonticidal antimalarial activity against Plasmodium berghei (sensitive strain) in mice (Mus musculus) at 50 mg/kg/day x 4 (oral); indicates complete elimination of malaria parasites from the body, and animals survive up to day D+6 0 (survival=6/6) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA716861 | F | Compound was evaluated for the blood-schizonticidal antimalarial activity against Plasmodium yoelii nigeriensis (multidrug-resistant strain) in mice (Mus musculus) at 100 mg/kg/day x 4 (oral); indicates complete elimination of malaria parasites from the body, and animals survive up to day D | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA716863 | F | Compound was evaluated for the blood-schizonticidal antimalarial activity against Plasmodium yoelii nigeriensis (multidrug-resistant strain) in mice (Mus musculus) at 50 mg/kg/day x 4 (oral); indicates that all of the treated animals show negative parasitaemia up to D+7 (survival=4/6) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA760047 | F | Inhibitory activity I50 against chloroquine-sensitive Plasmodium falciparum | Plasmodium falciparum | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA2027593 | F | Inhibition of beta-hematin formation | 43 | assay format | Scientific Literature | |||
| 9. | ALA994373 | T | Toxicity against human erythrocytes assessed as potentiation of heme-induced hemolysis in presence of variable concentration of heme | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA994374 | F | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in human erythrocytes after 48 hrs | Plasmodium falciparum | 3 | organism-based format | Scientific Literature | ||
| 11. | ALA994375 | F | Inhibition of beta-hematin formation after 16 hrs | 3 | assay format | Scientific Literature | |||
| 12. | ALA994377 | B | Binding affinity to heme in HEPES buffer at pH 7.4 upto 60 uM after 30 mins by Jobs plot | 1 | assay format | Scientific Literature | |||
| 13. | ALA994379 | B | Binding affinity to heme in HEPES buffer at pH 7.4 after 30 mins by Hills plot | 3 | assay format | Scientific Literature | |||
| 14. | ALA994380 | T | Toxicity against human erythrocytes assessed as potentiation of heme-induced hemolysis at 10 uM in presence of heme | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA983747 | T | Toxicity against human erythrocytes assessed as heme-induced hemolysis up to 30 uM in absence of heme | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 16. | ALA1217067 | F | Antimalarial activity against chloroquine-resistant Plasmodium falciparum | Plasmodium falciparum | 16 | organism-based format | Scientific Literature | ||
| 17. | ALA1217086 | F | Antiplasmodial activity against Plasmodium berghei infected in mice (Mus musculus) assessed as suppression of parasitaemia at 100 mg/kg, po | Plasmodium berghei | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA1647372 | F | Inhibition of beta-hematin formation | 38 | assay format | Scientific Literature | |||
| 19. | ALA4193396 | F | Schizontocidal activity against chloroquine-sensitive Plasmodium falciparum after 3 days | Plasmodium falciparum | 2 | organism-based format | Scientific Literature |
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