| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2432392 | B | Selectivity ratio of IC50 for recombinant human MMP-9 to IC50 for recombinant human ADAM-17 | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 2. | ALA2432393 | B | Selectivity ratio of IC50 for recombinant human MMP-14 to IC50 for recombinant human ADAM-17 | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 3. | ALA2432394 | B | Selectivity ratio of IC50 for recombinant human MMP-2 to IC50 for recombinant human ADAM-17 | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 4. | ALA2432395 | B | Inhibition of recombinant human MMP-9 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 4 hrs measured every 15 secs for 20 mins by fluorimetric assay | Homo sapiens | 16 | single protein format | Scientific Literature | ||
| 5. | ALA2432396 | B | Inhibition of recombinant human ADAM-10 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 1 hr measured every 15 secs for 20 mins by fluorimetric assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 6. | ALA2432397 | B | Inhibition of recombinant human MMP-14 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 4 hrs measured every 15 secs for 20 mins by fluorimetric assay | Homo sapiens | 20 | single protein format | Scientific Literature | ||
| 7. | ALA2432398 | B | Inhibition of recombinant human MMP-2 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 4 hrs measured every 15 secs for 20 mins by fluorimetric assay | Homo sapiens | 20 | single protein format | Scientific Literature | ||
| 8. | ALA2432517 | B | Inhibition of recombinant human MMP-1 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 4 hrs measured every 15 secs for 20 mins by fluorimetric assay | Homo sapiens | 20 | single protein format | Scientific Literature | ||
| 9. | ALA2432518 | B | Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs for 20 mins by fluorimetric assay | Homo sapiens | 20 | single protein format | Scientific Literature | ||
| 10. | ALA2432519 | B | Inhibition of ADAM-17 in human SKOV3 cells transfected with luciferase gene assessed as inhibition of pervanadate-induced sALCAM release incubated for 30 mins prior to pervanadate induction measured after 90 mins by ELISA | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 11. | ALA2434047 | A | Cytotoxicity against human A2780 cells assessed as cell viability at 0.01 to 10 uM after 24 to 72 hrs by MTT assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 12. | ALA2434048 | A | Cytotoxicity against human A2774 cells assessed as cell viability at 0.01 to 10 uM after 24 to 72 hrs by MTT assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 13. | ALA2434049 | A | Cytotoxicity against human SKOV3 cells transfected with luciferase gene assessed as cell viability at 0.01 to 10 uM after 24 to 72 hrs by MTT assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 14. | ALA2434050 | B | Inhibition of ADAM-17 in human A2780 cells assessed as inhibition of EGF-induced sALCAM release incubated for 30 mins prior to EGF induction measured after 18 hrs by ELISA | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 15. | ALA2434051 | B | Inhibition of ADAM-17 in human A2780 cells assessed as inhibition of pervanadate-induced sALCAM release incubated for 30 mins prior to pervanadate induction measured after 90 mins by ELISA | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 16. | ALA2434052 | B | Inhibition of ADAM-17 in human SKOV3 cells transfected with luciferase gene assessed as inhibition of EGF-induced sALCAM release incubated for 30 mins prior to EGF induction measured after 18 hrs by ELISA | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 17. | ALA2434053 | B | Inhibition of ADAM-17 in human A2774 cells assessed as inhibition of EGF-induced sALCAM release incubated for 30 mins prior to EGF induction measured after 18 hrs by ELISA | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 18. | ALA2434054 | B | Inhibition of ADAM-17 in human A2774 cells assessed as inhibition of pervanadate-induced sALCAM release incubated for 30 mins prior to pervanadate induction measured after 90 mins by ELISA | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 19. | ALA5229257 | B | Inhibition of human recombinant ADAM8 using PepDAB13 as substrate preincubated with enzyme for 45 mins followed by substrate addition and measured for 6 hrs by fluorometric assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 20. | ALA5229258 | B | Inhibition of recombinant ADAM17 (unknown origin) using PepDAB13 as substrate preincubated with enzyme for 45 mins followed by substrate addition and measured for 6 hrs by fluorometric assay | Homo sapiens | 4 | single protein format | Scientific Literature |
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