# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2439864 | Binding | Inhibition of PTP1B in rat L6 cells assessed as insulin-induced Akt phosphorylation preincubated for 2 hrs followed by insulin challenge for 10 mins by Western blotting analysis | Rattus norvegicus | 1 | ALA2434820 | cell-based format | Scientific Literature | |
2. | ALA2439865 | Binding | Inhibition of PTP1B in rat L6 cells assessed as insulin-stimulated 2-deoxy-[3H]-deoxy-glucose uptake at 20 uM preincubated for 2 hrs followed by insulin challenge for 30 mins | Rattus norvegicus | 1 | ALA2434820 | cell-based format | Scientific Literature | |
3. | ALA2439866 | Binding | Inhibition of PTP1B in rat L6 cells assessed as insulin-stimulated 2-deoxy-[3H]-deoxy-glucose uptake at 10 uM preincubated for 2 hrs followed by insulin challenge for 30 mins | Rattus norvegicus | 1 | ALA2434820 | cell-based format | Scientific Literature | |
4. | ALA2439867 | Binding | Inhibition of PTP1B in rat L6 cells assessed as insulin-stimulated 2-deoxy-[3H]-deoxy-glucose uptake preincubated for 2 hrs followed by insulin challenge for 30 mins | Rattus norvegicus | 1 | ALA2434820 | cell-based format | Scientific Literature | |
5. | ALA2439868 | Binding | Inhibition of PTP1B in rat L6 cells assessed as insulin-induced Akt phosphorylation at 20 uM preincubated for 2 hrs followed by insulin challenge for 10 mins by Western blotting analysis in presence of wortmannin | Rattus norvegicus | 1 | ALA2434820 | cell-based format | Scientific Literature | |
6. | ALA2439869 | Binding | Inhibition of PTP1B in rat L6 cells assessed as insulin-induced Akt phosphorylation at 5 to 10 uM preincubated for 2 hrs followed by insulin challenge for 10 mins by Western blotting analysis | Rattus norvegicus | 1 | ALA2434820 | cell-based format | Scientific Literature | |
7. | ALA2439870 | Binding | Selectivity ratio of IC50 for SHP-2 (unknown origin) to IC50 for GST-tagged PTP1B (unknown origin) | Homo sapiens | 1 | ALA2434820 | assay format | Scientific Literature | |
8. | ALA2439871 | Binding | Selectivity ratio of IC50 for LAR (unknown origin) to IC50 for GST-tagged PTP1B (unknown origin) | Homo sapiens | 1 | ALA2434820 | assay format | Scientific Literature | |
9. | ALA2439872 | Binding | Selectivity ratio of IC50 for SHP-1 (unknown origin) to IC50 for GST-tagged PTP1B (unknown origin) | Homo sapiens | 1 | ALA2434820 | assay format | Scientific Literature | |
10. | ALA2439873 | Binding | Selectivity ratio of IC50 for TCPTP (unknown origin) to IC50 for GST-tagged PTP1B (unknown origin) | Homo sapiens | 5 | ALA2434820 | assay format | Scientific Literature | |
11. | ALA2439874 | Binding | Selectivity ratio of IC50 for CDC25B (unknown origin) to IC50 for GST-tagged PTP1B (unknown origin) | Homo sapiens | 1 | ALA2434820 | assay format | Scientific Literature | |
12. | ALA2437793 | Binding | Inhibition of LAR (unknown origin) | Homo sapiens | 5 | ALA2434820 | single protein format | Scientific Literature | |
13. | ALA2437794 | Binding | Inhibition of CDC25B (unknown origin) | Homo sapiens | 5 | ALA2434820 | single protein format | Scientific Literature | |
14. | ALA2437795 | Binding | Inhibition of TCPTP (unknown origin) | Homo sapiens | 5 | ALA2434820 | single protein format | Scientific Literature | |
15. | ALA2437796 | Binding | Inhibition of PTP1B (unknown origin) expressed in CHO cells over-expressing human IR assessed as increase in insulin-mediated IR-beta phosphorylation preincubated for 2 hrs followed by insulin challenge for 10 mins by Western blotting analysis | Homo sapiens | 8 | ALA2434820 | cell-based format | Scientific Literature | |
16. | ALA2437798 | Binding | Inhibition of SHP-1 (unknown origin) | Homo sapiens | 5 | ALA2434820 | single protein format | Scientific Literature | |
17. | ALA2437799 | Binding | Inhibition of SHP-2 (unknown origin) | Homo sapiens | 5 | ALA2434820 | single protein format | Scientific Literature | |
18. | ALA2437800 | Binding | Inhibition of GST-tagged PTP1B (unknown origin) using pNPP as substrate measured for 2 mins by colorimetric analysis | Homo sapiens | 29 | ALA2434820 | single protein format | Scientific Literature |